Evidence map›Paper›PMID 41978186›Full record

ArticleNutrients2026

Dietary Patterns and Cerebral Glucose Metabolism in Older Adults: Findings from the Western Australian Memory Study.

Carolina B Castro, Samantha L Gardener, Farzana Jahan, Juliana Chen, Belinda M Brown, Ruey L Loo, Kevin Taddei, Stephanie R Rainey-Smith, Michael Weinborn, Ana Caroline R Dos Reis and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Carolina B CastroCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0001-7176-4823
Samantha L GardenerAlzheimer's Research Australia, Nedlands, WA 6009, Australia.ORCID 0000-0002-1933-5260
Farzana JahanCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0002-0300-6315
Juliana ChenThe University of Sydney, Faculty of Medicine and Health, Camperdown, NSW 2006, Australia.ORCID 0000-0003-2844-6947
Belinda M BrownCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.
Ruey L LooAustralian National Phenome Centre and Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.ORCID 0000-0001-5307-5709
Kevin TaddeiAlzheimer's Research Australia, Nedlands, WA 6009, Australia.ORCID 0000-0002-8106-7957
Stephanie R Rainey-SmithCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.
Michael WeinbornSchool of Psychological Science, The University of Western Australia, Crawley, WA 6009, Australia.
Ana Caroline R Dos ReisState University of Bahia (UNEB), Department of Life Sciences, Salvador 41150-000, BA, Brazil.
Shipra VermaDepartment of Nuclear Medicine, PET CT and Radionuclide Therapy, Fiona Stanley Hospital, Murdoch, WA 6150, Australia.
Nick CarriganThe UWA Medical School, The University of Western Australia, Perth, WA 6009, Australia.
Charles InderjeethSchool of Medicine, The University of Western Australia, Crawley, WA 6009, Australia.
Vincent DoréHealth and Biosecurity Flagship, Australian eHealth Research Centre, CSIRO, Parkville, VIC 3052, Australia.
Manohar L GargMacquarie Medical School, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0003-0514-0865
Ralph N MartinsAlzheimer's Research Australia, Nedlands, WA 6009, Australia.ORCID 0000-0002-4828-9363
Hamid R SohrabiCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0001-8017-8682

Funding

NHMRC #324100; Molecular and Neuropsychological Predictive Markers of Cognitive Decline)
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by significant reductions in glucose metabolism, reflecting underlying synaptic dysfunction, correlating with cognitive decline. We aimed to explore the impact of dietary patterns on the change in glucose metabolism.

methodsThis longitudinal, prospective study included 132 community-dwelling older adults without a diagnosed dementia history enrolled in the Western Australian Memory Study (WAMS). Participants completed a food frequency questionnaire at baseline and underwent [

resultsAdherence to a Western Diet, characterized by high sugars and saturated fats, was associated with faster decline in glucose metabolism in the left fusiform gyrus (β = -0.00062; SE = 0.00025; FDR-adjusted

conclusionsOur study highlights the following: (a) The potential detrimental impact of a Western Diet on brain glucose metabolism, particularly for females, who are at higher risk for AD. The decline was observed in regions essential for cognitive functions, including visual processing and facial recognition, emphasizing the role of diet in brain health. (b) No significant associations were observed between adherence to a Prudent dietary pattern and changes in glucose metabolism.

Indexed as

BrainDiet, WesternGlucoseAgedAged, 80 and overAlzheimer DiseaseFemaleFluorodeoxyglucose F18HumansLongitudinal StudiesMaleMemoryPositron-Emission TomographyProspective StudiesWestern AustraliaFluorodeoxyglucose F18GlucoseAlzheimer’s diseasedietary patternsFDG PETglucose metabolismPrudent DietWestern Australian Memory StudyWestern Diet

Identifiers

PMID41978186
PMCPMC13074405

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.