ReviewGlobal cardiology science & practice2025
Therapy-induced cardiotoxicity in drug-resistant tuberculosis patients: A systematic review and meta-analysis.
Review in Global cardiology science & practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ag85A-PEGylated Propolis Nanoparticles Exhibit Intracellular Antimycobacterial and Host-Protective Activities AgainstInternational journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug-resistant tuberculosis remains a major public health challenge with substantial associated morbidity and mortality. Management requires complex, individualized treatment regimens. Emerging evidence suggests that contemporary antituberculosis agents for drug-resistant disease carry significant cardiotoxicity risk. This study aims to evaluate the cardiovascular toxicity of current therapeutic regimens in patients with multidrug-resistant, pre-extensively drug-resistant, and extensively drug-resistant tuberculosis.
methodsThis systematic review and meta-analysis was conducted following the PRISMA guidelines. A comprehensive literature search was performed across five databases (PubMed, Cochrane Library, Scopus, ProQuest, and Springer) through May 5, 2024. Methodological quality was assessed using NHLBU study quality assessment tools for controlled intervention studies. Statistical analyses were conducted using a random-effects model with the DerSimonian-Laird method, with results reported as pooled estimates with 95% confidence intervals.
resultsEight studies comprising 9,506 patients with multidrug-resistant, pre-extensively drug-resistant, and extensively drug-resistant tuberculosis were included. Bedaquiline without delamanid was associated with the greatest QTc prolongation [pooled mean difference: 21.9 ms (95% CI [10.24-33.62])] and highest prevalence of clinically significant QTc prolongation [21.2% (95% CI [8.6-22.8]%)]. Treatment discontinuation rates were similar for bedaquiline monotherapy and bedaquiline-delamanid combination therapy [8% (95% CI [2-18]%) vs. 8% (95% CI [0-21]%)].
conclusionDrug resistant tuberculosis treatments were associated with cardiotoxicity concerns, evidenced by its QT prolongation, clinically significant arrhythmia, and treatment discontinuation.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.