ReviewGlobal cardiology science & practice2025
Neurocognitive outcomes and memory transfer in heart transplantation.
Review in Global cardiology science & practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Qur'anic heart and converging evidence from contemporary cardiac science: From qalb to cardioception.Journal of Taibah University Medical Sciences · 2026Review
- Correction to "Neurocognitive outcomes and memory transfer in heart transplantation".Global cardiology science & practice · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCardiac transplantation remains a life-saving intervention for end-stage cardiac disease, substantially improving survival and quality of life. While physiological and immunological challenges, such as graft rejection and immunosuppression, are well-characterized, emerging evidence underscores complex neurocognitive and psychological transformations in recipients. These include debated phenomena such as shifts in memory, behavior, and personality, which challenge conventional paradigms of transplantation outcomes. METHODOLOGY: This scoping review was conducted by performing comprehensive literature searches of databases including PubMed, Scopus, Google Scholar, Cochrane Library, and PsycINFO using MeSH keywords: "heart transplant", "neurocognitive outcomes", "cellular memory", AND "personality transfer". The timeline spanned 1990 through June 2025. INCLUSION CRITERIA: (1) peer-reviewed clinical studies; (2) case reports providing detailed narrative descriptions relevant to memory/personality changes; (3) manuscripts written in English; (4) reports including ≥5 participants/patients. EXCLUSION CRITERIA: (1) non-transplant cardiac studies; (2) animal research; (3) editorials/opinions/gray literature; (4) non-English manuscripts. Study quality was assessed through manual review of documented accounts alongside corresponding peer-reviewed manuscripts.
resultsThis review synthesizes theories, case studies, and mechanistic hypotheses from published reports, exploring neurocognitive trajectories and purported memory-behavioral transfer between donors and recipients. Epigenetic modifications-such as DNA methylation and histone remodeling-are hypothesized to alter gene expression in donor-derived cells, potentially influencing recipient cognition and behavior. Concurrently, immune-brain crosstalk, mediated by cytokines and neuroinflammatory pathways, may exacerbate psychological distress, including identity dissonance and anxiety. Cognitive-behavioral interventions and psychosocial support emerge as critical tools for post-transplant adaptation.
conclusionCurrent evidence on memory transfer remains inconclusive, yet its implications for biological-psychological interconnectedness warrant rigorous interdisciplinary inquiry. By integrating neuroscientific, immunological, and psychological frameworks, future research can elucidate the mechanisms underlying post-transplant neurocognitive phenomena, optimizing therapeutic strategies and patient counseling.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.