Evidence map›Paper›PMID 41978746›Full record

ArticleRSC advances2026

Hybrid benzylidene thiazolidine-2,4-diones as potent apoptosis-inducing anticancer agents: design-driven optimization, cytotoxic profiling, and mechanistic validation in prostate cancer.

Saad Shaaban, Samia S Hawas, Marwa Sharaky, Hussein Ba-Ghazal, Ayman Abo Elmaaty, Khadra B Alomari, Mohamed Alaasar, Asma M Elsharif, Fatema S Alatawi, Mohamed Alaa Mohamed and 2 more

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saad ShaabanDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa.ORCID https://orcid.org/0000-0002-7835-6926
Samia S HawasDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt akarmalawy@horus.edu.eg.
Marwa SharakyCancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University Cairo Egypt.
Hussein Ba-GhazalDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia sibrahim@kfu.edu.sa.
Ayman Abo ElmaatyMedicinal Chemistry Department, Faculty of Pharmacy, Port Said University Port Said 42526 Egypt.
Khadra B AlomariJazan University, Department of Physical Sciences, Chemistry Division 45142 Jazan Kingdom of Saudi Arabia.
Mohamed AlaasarDepartment of Chemistry, Faculty of Science, Cairo University Giza Egypt.ORCID https://orcid.org/0000-0003-4155-8644
Asma M ElsharifDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University Dammam 31441 Saudi Arabia.
Fatema S AlatawiDepartment of Biochemistry, Faculty of Science, University of Tabuk Tabuk Saudi Arabia.
Mohamed Alaa MohamedDepartment of Chemistry, Faculty of Science, Mansoura University Mansoura Egypt.
Arwa Omar Al KhatibFaculty of Pharmacy, Al-Ahliyya Amman University Amman Jordan.
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt akarmalawy@horus.edu.eg.ORCID https://orcid.org/0000-0002-8173-6073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The smart combination of fragment merging, bioisosteric replacement, and conformational rigidification allowed for the design of a new series of

Identifiers

PMID41978746
PMCPMC13070299

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.