Evidence map›Paper›PMID 41978994›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Elevation in network dynamics amplifies amyloid-dependent tau pathology.

Jieying Li, Yang Yi, Lin Gan, Gleb Bezgin, Tevy Chan, Nesrine Rahmouni, Yi-Ting Wang, Etienne Aumont, Seyyed Ali Hosseini, Brandon J Hall and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Jieying LiTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Yang YiSichuan Provincial Centre for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Lin GanThe Clinical Hospital of Chengdu Brain Science Institute, Brain-Computer Interface & Brain-Inspired Intelligence Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Gleb BezginTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Tevy ChanTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Nesrine RahmouniTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Yi-Ting WangTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Etienne AumontTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Seyyed Ali HosseiniTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Brandon J HallTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Lydia TrudelTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Joseph TherriaultTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Arthur C MacedoTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Kely Monica Quispialaya SocualayaTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Jaime Fernandez AriasTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Yansheng ZhengTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Delphine Olivia-LopezTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Robert HopewellPET Unit, McConnell Brain Imaging Centre, Montreal, Quebec, Canada.
Chris Hung-Hsin HsiaoPET Unit, McConnell Brain Imaging Centre, Montreal, Quebec, Canada.
Ting ZouThe Clinical Hospital of Chengdu Brain Science Institute, Brain-Computer Interface & Brain-Inspired Intelligence Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Jean-Paul SoucyTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Serge GauthierTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Paolo VitaliTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Tharick A PascoalDepartment of Psychiatry School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Qolamreza R RazlighiDepartment of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, New York, USA.
Maxime MontembeaultDouglas Research Centre & Department of Psychiatry, McGill University, Montréal, Quebec, Canada.
Rong LiThe Clinical Hospital of Chengdu Brain Science Institute, Brain-Computer Interface & Brain-Inspired Intelligence Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory Department of Neurology and Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Funding

Brain Canada Foundation 33397Brain Canada Foundation CFI Project 34874Brain Science and Brain-like Intelligence Technology-National Science and Technology Major Project 2022ZD0208903Canadian Consortium of Neurodegeneration and Aging MOP-11-51-31 -team 1CIHR 159815CIHR 162303CIHR MOP-11-51-31CIHR RFN 152985Consortium canadien en neurodégénérescence associée au vieillissementFondation Brain CanadaLingang Laboratory LGL-1630-05National Natural Science Foundation of China 823720853the Alzheimer's Association NIRG-12-92090the Alzheimer's Association NIRP-12-259245the Fonds de Recherche du Québec-Santé 2024-VICO-356138the Fonds de Recherche du Québec-Santé Chercheur Boursier 2020-VICO-279314Weston Brain Institute
6 · The paper itself

Abstract

introductionThe role of brain network dynamics in relation to amyloid beta (Aβ) and tau pathology across Braak stages remains unclear.

methodsIn this cross-sectional study of 216 participants from Translational Biomarkers of Aging and Dementia (TRIAD) cohort, we analyzed resting-state functional magnetic resonance imaging using a multilayer modularity algorithm to assess brain network dynamics across 10 predefined functional networks, stratified by amyloid and tau positron emission tomography biomarkers and Braak stages.

resultsSwitching rates were significantly elevated in Aβ-positive/tau-positive individuals relative to Aβ-negative/tau-negative individuals, and increased progressively with advancing Braak stages. Elevated switching rates were strongly correlated with Aβ and tau burden in dorsal attention network and sensorimotor network, as well as with cognitive severity. Importantly, the interaction between network switching rate and Aβ burden synergistically contributed to accelerated tau accumulation in Braak stage III to V regions. DISCUSSION: These findings support the framework that increased network switching may amplify Aβ-related tau load and cognitive deterioration in Alzheimer's disease.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainNerve Nettau ProteinsAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMalePositron-Emission TomographyAmyloid beta-Peptidestau ProteinsAlzheimer's diseaseBraak stagingbrain networkcognitionpathology

Identifiers

PMID41978994
PMCPMC13077447

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.