Evidence map›Paper›PMID 41979147›Full record

ArticleThe Journal of physiology2026

Oleuropein-based olive leaf extract enhances muscle mitochondrial bioenergetics response to moderate - but not maximal - intensity exercise in humans.

Clément Lanfranchi, Alba Moreno-Asso, Astrid M H Horstman, Sara Mistro, Eugenia Migliavacca, Ornella Cominetti, Jens Stolte, Sylviane Métairon, Aurélie Hermant, Ane Laura Pedersen and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07729072 (The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07729072 nanot yet recruitingnot on this map

The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers

TypeinterventionalSponsorUniversity of LausanneRan2026 to 2029Enrolled60ConditionsHealthy Adult Participants, Exercise Training, Neuromuscular Adaptations, Nutritional InterventionArmsOlive leaf extract, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Clément LanfranchiInstitute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
Alba Moreno-AssoNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Astrid M H HorstmanNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-4866-7368
Sara MistroInstitute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
Eugenia MigliavaccaNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-1883-1972
Ornella CominettiNestlé Institute of Food Safety & Analytical Sciences, Nestlé Research, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-8564-1963
Jens StolteNestlé Institute of Food Safety & Analytical Sciences, Nestlé Research, Lausanne, Switzerland.
Sylviane MétaironNestlé Institute of Food Safety & Analytical Sciences, Nestlé Research, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-2434-8733
Aurélie HermantNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Ane Laura PedersenNestlé Institute of Food Safety & Analytical Sciences, Nestlé Research, Lausanne, Switzerland.ORCID https://orcid.org/0009-0009-2297-3448
Loïc DayonNestlé Institute of Food Safety & Analytical Sciences, Nestlé Research, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-8499-270X
Umberto De MarchiNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Jérôme N FeigeNestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-4751-264X
Nadège ZanouInstitute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
Nicolas PlaceInstitute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-9044-0621

Funding

University of Lausanne Institutional funding
6 · The paper itself

Abstract

Sprint interval exercise (SIE) induces skeletal muscle mitochondrial adaptations that are comparable to, or greater than, those observed with moderate-intensity continuous exercise (MICE), despite requiring a lower training volume. Previous work has shown that these adaptations are at least partly mediated by enhanced mitochondrial bioenergetics, including increased mitochondrial Ca

Indexed as

Energy MetabolismExerciseIridoidsMitochondria, MuscleOleaPlant ExtractsAdultAnimalsCalciumCross-Over StudiesDouble-Blind MethodHumansIridoid GlucosidesMaleMiceMuscle, SkeletalCalciumIridoid GlucosidesIridoidsoleuropeinPlant ExtractsPyruvate Dehydrogenase Complexcalcium mitochondriamuscle fatigueoxidative phosphorylationpower outputpyruvate dehydrogenase

Identifiers

PMID41979147
PMCPMC13178539

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.