ArticleClinical pharmacology and therapeutics2026
CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real-World Setting.
Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Implementation Imperative in Clinical Pharmacology.Clinical pharmacology and therapeutics · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from the UK Biobank. Importantly, CYP2C19 ultrarapid metabolizers (UMs) were more likely to experience therapeutic failure (OR 2.03, P = 0.002) and both CYP2C19 poor metabolizers (PMs) and UMs exhibited an increased likelihood of treatment resistance (PMs, OR 1.85, P = 0.06; UMs, OR 1.74, P = 0.05). Furthermore, inferred CYP2C19 metabolizer status showed significant monotonic trends with citalopram maintenance dose (from 19.7 mg/d in PMs to 24.4 mg/d in UMs; Jonckheere-Terpstra P = 0.017) and time to dose escalation (2.5 years in PMs to 1.7 years in UMs; P = 0.006). Besides CYP2C19, rare variant analyses identified BMP2K as a novel candidate locus for SSRI response. BMP2K variants were significantly associated with therapeutic failure in citalopram patients (P = 5.49 × 10
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