Trial reportPain management2026
Specific and shared mechanisms mediating pain intensity and functional outcomes in chronic neck pain.
Trial report in Pain management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05940012 (Specific and Shared Mechanisms Associated With Physical Therapy Interventions), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Specific and Shared Mechanisms Associated With Physical Therapy Interventions
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, very few studies have used mediation analysis to explore the reasons why people with chronic neck pain improve after physical therapy intervention involving manual therapy or exercise.
objectivesTo evaluate which specific mechanisms (mobility, pain modulation and endurance) and shared mechanisms (self-efficacy, working alliance, engagement, fear, and positive coping) mediated the effects of treatment on clinical outcomes at 4-weeks and 6-months in individuals with chronic neck pain.
methodsThe study incorporated planned indirect‑only mediation analyses to evaluate both specific and shared mechanisms as mediator using data from a mechanistic clinical trial comparing manual therapy and exercise interventions, which demonstrated no between‑group differences. Baseline pain intensity was modeled as the independent variable, and pain interference and physical function at four-weeks and six-months were specified as outcomes. Direct, indirect, and total effects were estimated across four mediation models.
resultsNone of the mediation analyses found specific or shared mechanisms that mediated the relationship of baseline pain intensity to long-term pain interference and physical function. Discussion/Conclusion: Our findings suggest that the absence of significant mediation implies that commonly targeted mechanisms may not be the primary drivers of the relationship of pain intensity to longer-term pain interference or physical function. CLINICAL
trial registrationwww.clinicaltrials.gov identifier is NCT05940012.
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