Evidence map›Paper›PMID 41979288›Full record

ArticleAging cell2026

Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the App

Eileen Mac Sweeney, Giulia Abate, Bjorn R V Bakker, Andrea Mastinu, Ylenia Lai, Daniela Uberti, Per Nilsson, Simone Tambaro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eileen Mac SweeneyDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Giulia AbateDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.ORCID 0000-0001-9161-3475
Bjorn R V BakkerDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Andrea MastinuDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.ORCID 0000-0002-8862-2896
Ylenia LaiDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Daniela UbertiDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Per NilssonDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Simone TambaroDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID 0000-0001-7000-7556

Funding

Åhlén-stiftelsen 223087Alzheimer's Association 24AARG-1244398DemensfondenGamla tjänarinnorGun & Bertil Stohnes StiftelseLindhés Advokatbyrå StiftelseOlle Engkvists Stiftelse 213-0295
6 · The paper itself

Abstract

Cellular senescence, a state of irreversible cell cycle arrest, plays a key role in neurodegenerative diseases, including Alzheimer's disease (AD). While senescent cells are emerging as potential therapeutic targets, the dynamics of their occurrence over time and the specific cell types most affected by AD are still not well understood. This study investigates age- and pathology-dependent changes in senescence markers, specifically p16, p21, and p53, using the amyloidogenic App

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21NeurogliaTumor Suppressor Protein p53AgingAnimalsAstrocytesDisease Models, AnimalFemaleMiceMice, TransgenicMicrogliaAmyloid beta-Protein PrecursorCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Tumor Suppressor Protein p53Alzheimer's diseaseApp NL‐G‐Fp16p21p53senescence

Identifiers

PMID41979288
PMCPMC13078136

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.