ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026
A case report about extracranial skeletal metastases in pediatric diffuse midline glioma, H3 K27-altered.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report a rare case of diffuse midline glioma, H3K27-altered (DMG), with extracranial metastases in a 9-year-old boy. The patient, initially treated with standard chemoradiotherapy, developed radiographically confirmed vertebral and peritoneal metastases within several months. Despite aggressive therapy, survival was short, underscoring the dismal prognosis associated with extraneural dissemination in DMG. Characteristic imaging findings and potential mechanisms of metastasis are discussed. This case highlights the need for early recognition and comprehensive systemic evaluation in managing atypical metastatic patterns of DMG.
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