Evidence map›Paper›PMID 41980770›Full record

ArticleGenes & development2026

DAXX directs dual modes of H3.4-to-H3.3 histone replacement in the male germline.

Yu-Han Yeh, Mengwen Hu, Kai Otsuka, Brooke M Alger, Shruti S Nene, Han Wang, So Maezawa, Satoshi H Namekawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu-Han YehDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616, USA.ORCID 0000-0003-2369-4415
Mengwen HuDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616, USA.ORCID 0000-0002-7480-6432
Kai OtsukaDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba 281-8510, Japan.ORCID 0000-0002-7573-010X
Brooke M AlgerDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616, USA.
Shruti S NeneDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616, USA.
Han WangDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616, USA.
So MaezawaDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba 281-8510, Japan.ORCID 0000-0002-9060-2042
Satoshi H NamekawaDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616, USA; snamekawa@ucdavis.edu.ORCID 0000-0002-1052-943X

Funding

ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
Epigenetic gene regulations in the germlineR35GM141085 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satoshi Namekawa · 2021 to 2026
$4.4M
NIEHS NIH HHS T32 ES007059NIGMS NIH HHS R35 GM141085
6 · The paper itself

Abstract

During spermatogenesis, extensive chromatin remodeling and histone replacement reshape the male germline epigenome. Although HIRA mediates transcription-coupled incorporation of histone variant H3.3, we identified DAXX as a key histone chaperone directing genome-wide, transcription-coupled replacement of H3.4 (H3T) with H3.3 on autosomes during male meiosis. Simultaneously, DAXX also directs transcription-independent H3.4-to-H3.3 replacement on the sex chromosomes during meiotic sex chromosome inactivation (MSCI). These distinct, chromosome-specific modes of DAXX-mediated H3.3 deposition are essential for epigenomic integrity in the male germline. Loss of DAXX disrupts this process, resulting in widespread transcriptional dysregulation in haploid round spermatids and impaired male fertility.

Indexed as

Adaptor Proteins, Signal TransducingHistonesNuclear ProteinsAnimalsCo-Repressor ProteinsHistone ChaperonesMaleMeiosisMiceMolecular ChaperonesSex ChromosomesSpermatogenesisAdaptor Proteins, Signal TransducingCo-Repressor ProteinsDaxx protein, mouseHistone ChaperonesHistonesMolecular ChaperonesNuclear ProteinsDAXXhistone chaperonemeiosismeiotic sex chromosome inactivationspermatogenesis

Identifiers

PMID41980770
PMCPMC13224863

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.