Evidence map›Paper›PMID 41980991›Full record

ArticleNPJ primary care respiratory medicine2026

External validation of an IOS-derived model for airflow obstruction and COPD in a community-based cohort.

Lifei Lu, Jieqi Peng, Si Li, Gaoying Tang, Fan Wu, Qi Wan, Zhishan Deng, Cuiqiong Dai, Kunning Zhou, Xiaohui Wu and 11 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ primary care respiratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lifei Lu *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jieqi Peng *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Si Li *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Gaoying Tang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Fan WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qi WanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhishan DengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Cuiqiong DaiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kunning ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaohui WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Heshen TianDepartment of Respiratory and Critical Care Medicine Key Laboratory of Respiratory Disease of Zhejiang Province, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Xiangqing HouGuangzhou National Laboratory, Guangzhou, China.
Guannan CaiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Junfeng LinState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Suyin HuangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shuqing YuLianping County People's Hospital, Heyuan, China.
Yongqing HuangLianping County People's Hospital, Heyuan, China.
Changli YangWengyuan County People's Hospital, Shaoguan, China.
Shengtang ChenWengyuan County People's Hospital, Shaoguan, China.
Pixin RanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. pxran@gzhmu.edu.cn.
Yumin ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. zhouyumin410@126.com.

Funding

Foundation of Guangzhou National Laboratory SRPG22-016 and SRPG22-018Major Clinical Research Project of Guangzhou Medical University's Scientific Research Capability Improvement Plan GMUCR2024-01012R&D Program of Guangzhou National Laboratory SRPG23-005the Clinical and Epidemiological Research Project of State Key Laboratory of Respiratory Disease SKLRD-L-202402Zhongnanshan Medical Foundation of Guangdong Province ZNSXS-20250019
6 · The paper itself

Abstract

A model based on impulse oscillometry (IOS) predicting airflow limitation and chronic obstructive pulmonary disease (COPD) has been developed in hospital-based populations. However, its diagnostic performance in community-recruited cohorts and its potential complementary value when combined with commonly used questionnaire-based tools remain to be evaluated. To externally validate the IOS-derived model for airflow obstruction (AO) and COPD in a community-based cohort, and to assess whether combining it with the COPD Screening Questionnaire (COPD-SQ) improves diagnostic accuracy compared to either tool alone. This was a cross-sectional analysis of baseline data from the ongoing Early Chronic Obstructive Pulmonary Disease (ECOPD) prospective cohort study. Participants completed pre-bronchodilator IOS tests, pre- and post-bronchodilator spirometry tests. The previously developed IOS-derived model (incorporating age, sex, height, weight, and IOS parameters) was applied to this Chinese population cohort. The COPD-SQ (7 items) was also administered. We defined a pre-bronchodilator FEV

Indexed as

OscillometryPulmonary Disease, Chronic ObstructiveAgedCross-Sectional StudiesFemaleForced Expiratory VolumeHumansMaleMiddle AgedProspective StudiesROC CurveSpirometrySurveys and Questionnaires

Identifiers

PMID41980991
PMCPMC13270139

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.