Evidence map›Paper›PMID 41981673›Full record

ReviewReproductive biology and endocrinology : RB&E2026

Synthetic embryos: current progress, application and challenges.

Luyao Wang, Fucheng Guo, Yurong Chen, Xiangpeng Dai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luyao Wang *Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China.
Fucheng Guo *Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China.
Yurong ChenReproductive Medicine Center, Xiamen University Affiliated Chenggong Hospital, Xiamen, Fujian, China.
Xiangpeng DaiKey Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China. daixiangpeng@jlu.edu.cn.

Funding

National Natural Science Foundation of China 82273137
6 · The paper itself

Abstract

Synthetic embryos, generated using stem cells or reprogrammed somatic cells, could recapitulate embryo development in vitro and provide unique opportunities for in-depth study of embryogenesis, particularly human embryogenesis. To date, the synthetic embryos for human, mouse, non-human primates and bovine are successfully generated. Here we summarize and discuss the research progresses of synthetic embryos, including the materials used for generating synthetic embryos, the potential applications, and current challenges for the generation and application of synthetic embryos. In this review, we discuss the function of synthetic embryos in the study of embryo development, drug screening, genetic disease and organ transplantation.

Indexed as

Embryo, MammalianEmbryonic DevelopmentAnimalsHumansDisease modelDrug screeningEmbryogenesisStem cellsSynthetic embryo

Identifiers

PMID41981673
PMCPMC13188332

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.