Evidence map›Paper›PMID 41981678›Full record

ArticleJournal of nanobiotechnology2026

Microenvironment-responsive tetrahedral DNA nanoplatform for specific and enhanced tumor therapy through differential ROS and angiogenesis modulation.

Meiling Liu, Mengke Fan, Yu Guo, Mingya Tan, Taotao Chu, Linlin Huo, Jiayi Zhao, Xianghua Yang, Xiaojing He, Zhenghuan Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meiling LiuCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Mengke FanCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Yu GuoDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Mingya TanCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Taotao ChuCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Linlin HuoCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Jiayi ZhaoCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Xianghua YangCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Xiaojing HeDepartment of Radiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. he_xiaojing@hospital.cqmu.edu.cn.
Zhenghuan ZhaoCollege of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China. roddirck@cqmu.edu.cn.

Funding

Chongqing Medical University Graduate Top Talent Program BJRC202312Chongqing Natural Science Foundation Project CSTB2024NSCQ-MSX0616Graduate Scientific Research and Innovation Project of Chongqing CYB240192Natural Science Foundation of Chongqing CSTB2023NSCQ-LZX0033Program for Youth Innovation in Future Medicine, Chongqing Medical University W0105the Science and Health Joint Medical Research Project of Chongqing 2024ZDXM004
6 · The paper itself

Abstract

Achieving spatiotemporally differential regulation of therapeutic activity between tumors and normal tissues remaines a paramount challenge in precision nanomedicine. To address this challenge, an intelligent nanostructure is engineered by assembling the DNAzyme-integrated tetrahedral DNA (TDN) and pyropheophorbide-a (PPa) on MnO nanoparticles (NPs), which is abbreviated as TDN-MPs. Specifically, TDN-MPs generate reactive oxygen species (ROS) under laser irradiation and exhibit excellent photodynamic therapy (PDT) activity to kill tumor cells. The Mn

Indexed as

DNANanoparticlesNeovascularization, PathologicReactive Oxygen SpeciesTumor MicroenvironmentAnimalsCell Line, TumorChlorophyllidesDNA, CatalyticDNA NanostructuresHumansManganese CompoundsMiceOxidesPhotochemotherapyVascular Endothelial Growth Factor Receptor-2ChlorophyllidesDNADNA, CatalyticManganese Compoundsmanganese oxideOxidesReactive Oxygen SpeciesVascular Endothelial Growth Factor Receptor-2DNAzymeROS scavenger/generatorTetrahedral DNAtumor therapyVEGF regulation

Identifiers

PMID41981678
PMCPMC13200445

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.