Evidence map›Paper›PMID 41981708›Full record

ReviewNeurogastroenterology and motility2026

International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease.

Pascal de Santa Barbara, Isabella Ceccherini, Robert O Heuckeroth, Carlo Di Lorenzo, Maria M Alves, Arthur Beyder, Osvaldo Borrelli, Ludovica Cacopardo, Rachel Ceron, Jihong Chen and 33 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Pascal de Santa BarbaraPhysiology and Experimental Medicine of the Heart and Muscles (PhyMedExp), University of Montpellier, INSERM, CNRS, Montpellier, France.
Isabella CeccheriniUOSD Aggregation Area of the Research Laboratories, IRCCS Giannina Gaslini Institute, Genoa, Italy.
Robert O HeuckerothDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Carlo Di LorenzoNationwide Children's Hospital, Columbus, Ohio, USA.
Maria M AlvesDepartment of Clinical Genetics, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands.
Arthur BeyderEnteric Neuroscience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Osvaldo BorrelliNeurogastroenterology & Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital, London, UK.
Ludovica CacopardoDepartment of Information Engineering and Research Center 'E. Piaggio', University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-3148-9246
Rachel CeronDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jihong ChenFarncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Federica ChiapporiNational Research Council, Institute for Biomedical Technologies (CNR-ITB), Milano, Italy.
Antonio ContessaUniti per la PIPO-Patient Advocacy Organization, Brescia, Italy.
Roberto De GiorgioDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Antonella DiamantiDigestive Diseases and Nutritional Rehabylitation Pediatric Hospital Bambino Gesù, Rome, Italy.
Maria Grazia FaticatoPediatric Surgery, IRCCS Giannina Gaslini Institute, Genoa, Italy.
Sandrine FaurePhysiology and Experimental Medicine of the Heart and Muscles (PhyMedExp), University of Montpellier, INSERM, CNRS, Montpellier, France.
Sohaib K HashmiDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jan D HuizingaFarncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Raj P KapurDepartment of Laboratory Medicine and Pathology, Seattle Children's Hospital and University of Washington, Seattle, Washington, USA.
Cecile LambeDepartment of Pediatric Gastroenterology and Nutrition, Hospital Necker-Enfants Malades, Université Paris Cité, Paris, France.
Laurence LanconAssociation des POIC-Patient Advocacy Organization, Marseille, France.
Ryan McManigalWorld Visceral Myopathy Foundation, Dallas, Texas, USA.
Hayat MousaDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alessandro PalmitelliPoic e dintorni APS-Patient Advocacy Organization, Rome, Italy.
Victor PerreauxNantes Université, Inserm, TENS UMR1235, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France.ORCID https://orcid.org/0009-0007-8738-6813
Alessio Pini PratoUmberto Bosio Center for Digestive Diseases, The Children Hospital, AOU SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Michela PittoInstitute of Biophysics, National Research Council, Genoa, Italy.ORCID https://orcid.org/0009-0006-4830-1330
Elisa ProiettiU.O.C. Di.P.S, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
John RenduUniv. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institute Neurosciences, Grenoble, France.
Anna RybakNeurogastroenterology & Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital, London, UK.
Kenton M SandersDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, Nevada, USA.ORCID https://orcid.org/0000-0002-4196-1583
Sabah SardarJames Watt School of Engineering, University of Glasgow, Glasgow, UK.
Vincenzo StanghelliniAlma Mater Studiorum-Università di Bologna, Bologna, Italy.
Renato TambucciGastroenterology and Nutrition Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Nikhil ThaparStem Cell and Regenerative Medicine, GOS Institute of Child Health, University College London, London, UK.
Pieter Vanden BergheLaboratory for Enteric NeuroScience (LENS), TARGID, KU Leuven, University of Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-0009-2094
Massimo VassalliJames Watt School of Engineering, University of Glasgow, Glasgow, UK.
Qianqian WangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
Michael WanglerDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Sharon WolfsonDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0001-9085-1022
Almira ZadaDepartment of Biomedical Sciences, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia.ORCID https://orcid.org/0000-0002-1455-6857
Jiliang ZhouDepartment of Pharmacology, Toxicology & Neuroscience, LSU Health Shreveport, Shreveport, Louisiana, USA.
Federica VitiInstitute of Biophysics, National Research Council, Genoa, Italy.ORCID https://orcid.org/0000-0002-9651-8896

Funding

Posttranslational control of VSMC identity and vascular healthR01HL179809 · NHLBI · AUGUSTA UNIVERSITY · PI Huabo Su, Jiliang Zhou · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL179809
6 · The paper itself

Abstract

backgroundVisceral myopathy (VSCM) is an ultra-rare life-threatening condition characterized by severe impairment of gastrointestinal (GI), genitourinary, and uterine smooth muscle. This disorder represents a significant clinical challenge due to variable presentation and the lack of standardized diagnostic and therapeutic protocols.

methodsTo discuss advances in the field, scientists and clinicians with a special interest in VSCM met in Arenzano, Genova, Italy in October 2024 for the second International Forum on Visceral Myopathy 2024 (IFVM2024) (https://ifvm2024.ge.ibf.cnr.it/). KEY

resultsAs in the previous edition of the event (https://poic-e-dintorni.org/efvm-2022/), attendees included clinicians and researchers from around the world who study this disease, representatives from support organizations, patients affected by VSCM and their families, and companies that co-funded the event. The present manuscript aims to summarize knowledge shared during the IFVM2024 conference, thus providing an updated state-of-the-art summary of VSCM biology and disease management.

conclusionsHere, we pay particular attention to the epidemiology of the disease, histopathology, genetics, novel treatments, advances in molecular and cell biology, experimental models, and the lived experiences and impact of this disorder on families.

Indexed as

Muscular DiseasesAnimalsCongresses as TopicHumansACTG2CIPO and PIPOparenteral nutritionsmooth muscle cellsvisceral myopathy

Identifiers

PMID41981708
PMCPMC13079795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.