ArticleBiomaterial investigations in dentistry2026
Evaluation of an angio-osseo inductive bone ceramic versus demineralised freeze-dried bone allograft in the treatment of periodontal intrabony defects: a randomised controlled clinical trial.
Article in Biomaterial investigations in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Periodontal intrabony defects (IBDs) respond favourably to regenerative periodontal therapy. Various graft and non-graft materials have been used, with non-allogenic bone substitutes offering the potential to enhance clinical outcomes and radiographic defect resolution. Angio-Osseo Inductive Bone Ceramic (ABC), a novel ion-doped biphasic calcium phosphate graft, has shown promise due to its osteogenic and angiogenic potential. Aim: The study aimed to compare the clinical and radiographic outcomes of ABC and demineralised freeze-dried bone allograft (DFDBA) in the surgical management of periodontal IBDs. Materials & methods: A parallel-group, examiner- and statistician-blinded, randomised controlled clinical trial was conducted on 30 IBDs (one per patient), randomly assigned to ABC (test, Results: In both groups, mean IBD scores were significantly different at all time intervals ( Conclusion: Both ABC and DFDBA were effective in the treatment of periodontal IBDs. However, ABC demonstrated statistically significant improvement in defect fill, supporting its potential as a novel alloplastic alternative to conventional allograft.
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