Evidence map›Paper›PMID 41983192›Full record

ArticleFrontiers in cell and developmental biology2026

Enterococcus-driven metabolite-host gene networks in IBD-associated colorectal carcinogenesis: integrative multi-omics and experimental validation.

Gang Huang, Jiani Liu, Zhipeng Cheng, Yixin Chen, Kexin Chen, Wan Liu, Hancong Liu, Xinhao Xia, Man Lu, Wenxi Cui and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gang Huang *Department of Laboratory Medicine, Ganzhou Cancer Hospital, Ganzhou, Jiangxi, China.
Jiani Liu *Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Zhipeng Cheng *Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yixin Chen *The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Kexin Chen *The School of Public Health, Guangzhou Medical University, Guangzhou, China.
Wan LiuDepartment of Laboratory Medicine, Ganzhou Cancer Hospital, Ganzhou, Jiangxi, China.
Hancong LiuDepartment of Laboratory Medicine, Ganzhou Cancer Hospital, Ganzhou, Jiangxi, China.
Xinhao XiaThe First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Man LuThe School of Integrated Traditional Chinese and Western Medicine, Guangzhou Medical University, Guangzhou, China.
Wenxi CuiThe School of Integrated Traditional Chinese and Western Medicine, Guangzhou Medical University, Guangzhou, China.
Qingqing ZhangDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Yi YuanDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, GuangZhou, China.
Fei ZhongDepartment of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yiwen LiaoDepartment of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aims to elucidate the role of Enterococcusin the progression from inflammatory bowel disease to colorectal cancer (CRC), with a focus on identifying key metabolites and host genes regulated by Enterococcusand their influence on CRC development. Methods: Using the database gutMGene, gutMDisorder and MACdb, we mined the key metabolites and human genes. We acquired the activated genes (panel 1) and inhibited genes (panel 2), and metabolite associated genes (MAGs, panel 3). Subsequent analyses included protein-protein interaction (PPI) network construction, functional enrichment, differential expression and survival analysis in CRC, and immune infiltration assessment. Results: We screened 12 activated genes (Panel1: Conclusion:

Indexed as

bioinformaticscolitiscolorectal cancerenteritisEnterococcus

Identifiers

PMID41983192
PMCPMC13071049

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.