ArticleJournal of the American Heart Association2026
Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDegenerative valvular heart disease (VHD) is increasingly recognized as a major public health concern in aging populations. Although traditional cardiovascular risk factors have been extensively investigated, the role of loneliness and social isolation has remained largely overlooked in the context of valvular pathology.
methodsWe conducted a prospective cohort study involving 462 917 participants from the UK Biobank, free of VHDs at baseline. Loneliness and social isolation were assessed using validated questionnaires.
resultsDuring a median follow-up of 13.9 years, 11 003 cases of degenerative VHD were documented. Among them, there were 4280 cases of aortic valve stenosis and 4693 cases of mitral valve regurgitation. In fully adjusted models using no loneliness as reference, the highest loneliness level was associated with significantly increased risks of degenerative VHD (hazard ratio [HR], 1.19 [95% CI, 1.09-1.28]), aortic valve stenosis (HR, 1.21 [95% CI, 1.06-1.37]) and mitral valve regurgitation (HR, 1.23 [95% CI, 1.09-1.39]) (all
conclusionsLoneliness, rather than social isolation, was significantly associated with an increased risk of degenerative VHD. Our findings highlight novel opportunities for nonpharmacological interventions aimed at managing degenerative VHD.
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