ArticleInternational journal of fertility & sterility2026
Lean Polycystic Ovarian Syndrome Has Better Responses toRecombinant Follicle-Stimulating Hormone Compared to ObesePCOS during Ovarian Stimulation for
Article in International journal of fertility & sterility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obese or lean patients with polycystic ovarian syndrome (PCOS) may respond differently to Materials and Methods: This cross-sectional study recruited patients diagnosed with PCOS (according to Rotterdam criteria) undergoing IVF utilizing the gonadotropin-releasing hormone (GnRH) antagonist combined with rFSH protocol. The PCOS patients were grouped into lean PCOS [body mass index (BMI) < 23 kg/m Results: The mean age of the subjects was 32.7 ± 3.6 years. We found significant differences between the two groups in terms of the anti-müllerian hormone (AMH) levels (P=0.005), the initial dosage of rFSH (P<0.001), and cumulative doses of rFSH administered (P<0.001). However, the number of retrieved oocytes, endometrial thickness, cleavage rate, and pregnancy rates were comparable. Compared to the obese PCOS patients, the lean patients had higher AMH levels (8.80 vs. 6.85 ng/mL) and lower total dosages of rFSH (2128 ± 586 vs. 2752 ± 1136 IU). Conclusion: Individuals within the lean PCOS group exhibited elevated AMH levels and demonstrated a more favorable response to rFSH stimulation. Consequently, the lean PCOS group yielded more retrieved oocytes, while necessitating lower doses of rFSH stimulation compared to the obese PCOS group.
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