ArticleActa cirurgica brasileira2026
The beneficial effects of leave extract of Commiphora leptophloeos on intestinal mucositis induced by 5-fluorouracil in mice.
Article in Acta cirurgica brasileira, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to evaluate the effect of oral administration of a hydroethanolic extract of Commiphora leptophloeos leaves (CLF) on the progression of 5-fluorouracil (5-FU)-induced intestinal mucositis.
methodsFemale Swiss mice were orally administered CLF at doses of 10, 100, or 300 mg/kg, or saline (negative control, NC), starting 30 minutes before intraperitoneal injection of 5-FU. A positive control (PC) group received 5-FU without CLF treatment. Treatment continued until euthanasia, three days after 5-FU injection. Body weight was monitored throughout the experiment. On day 4, small intestine tissue samples were collected for histopathological analysis. Duodenal tissue was also assessed for Muc-2 immunostaining.
resultsIn the CLF 10, 100 and 300 mg/kg groups, the duodenum histopathological score was 1 (1-1.5) p < 0.001, 1 (1-1.5) p < 0.01; 1 (1-1.25) p < 0.01, while the PC group score was 2 (2-2.75). Immunostaining analysis for Muc-2 revealed a score of 3 (3-3) in the CLF 10 group, compared to score 1.2 (0.8-1.6) in the PC group (p < 0.001), indicating that CLF 10 increased Muc-2 expression.
conclusionThe oral administration of a hydroethanolic extract of CLF protected the duodenal segment of Swiss mice from 5-FU-induced intestinal mucositis, likely by increasing mucin production.
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