Evidence map›Paper›PMID 41984466›Full record

ArticleACS applied materials & interfaces2026

Biowaste-Archetyped Hierarchical Calcium Carbonate Nanoreactors Induce Tumor Bioenergetic Crisis and Reverse Cisplatin Resistance via Mitochondrial Metabolic Reprogramming.

Shupeng Shi, Haicong Liu, Qingping Peng, Shenao Nan, Shuyan Liu, Linna Wei, Haoyu Wang, Kai Wang, Xiaohong Zhong, Xin Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shupeng ShiDepartment of Plastic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Haicong LiuDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.
Qingping PengDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.
Shenao NanDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Shuyan LiuXiangya School of Medicine, Central South University, Changsha 410000, China.
Linna WeiXiangya School of Medicine, Central South University, Changsha 410000, China.
Haoyu WangXiangya School of Medicine, Central South University, Changsha 410000, China.
Kai WangDepartment of Plastic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Xiaohong ZhongDepartment of Plastic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
Xin ChenDepartment of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, China.
Wenzhe GaoDepartment of Hepatopancreatobiliary Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410000, China.ORCID 0000-0003-2383-2371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of next-generation nanotheranostics is increasingly challenged by the dual imperatives of environmental sustainability and the urgent need to overcome complex biological barriers, particularly multidrug resistance (MDR) in hepatocellular carcinoma (HCC). Herein, we bridge the gap between circular economy principles and precision nanomedicine by upcycling discarded eggshell membranes (ESM) into a hierarchical metabolic therapeutic platform. Utilizing the protein fiber network of ESM as a natural biotemplate, we orchestrated the anisotropic growth of calcium carbonate (CaCO

Indexed as

Antineoplastic AgentsCalcium CarbonateCarcinoma, HepatocellularCisplatinDrug Resistance, NeoplasmLiver NeoplasmsMitochondriaNanostructuresAnimalsCell Line, TumorEnergy MetabolismHumansMetabolic ReprogrammingMiceTumor MicroenvironmentAntineoplastic AgentsCalcium CarbonateCisplatinbiowaste upcyclingcalcium overloadhepatocellular carcinomamultidrug resistancetumor microenvironment

Identifiers

PMID41984466
PMCPMC13134627

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.