Evidence map›Paper›PMID 41985014›Full record

ArticleBlood advances2026

Zanubrutinib and pirtobrutinib show synergistic killing and suppression of BTK signaling in MYD88-mutated lymphoma cells.

Dominic Pizzarella, Amanda Kofides, John M Hatcher, Xia Liu, Alberto Guijosa, Nickolas Tsakmaklis, Abigail L Peachey, Jinhua Wang, Maria Luisa Guerrera, Christopher J Patterson and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Dominic PizzarellaBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0009-0003-1564-6867
Amanda KofidesBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
John M HatcherBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0002-3540-7842
Xia LiuBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Alberto GuijosaBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Nickolas TsakmaklisBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Abigail L PeacheyBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Jinhua WangDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.
Maria Luisa GuerreraBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0002-0730-4678
Christopher J PattersonBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Zachary R HunterBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0002-1689-1691
Hao SunBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Shayna R SarosiekBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Jorge J CastilloBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0001-9490-7532
Sara J BuhrlageDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.
Sirano Dhe-PaganonDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.
Andrew R BranaganMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-3868-9267
Steven P TreonBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0001-6393-6154
Shirong LiuBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0002-3821-9134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41985014
PMCPMC13315683

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.