Evidence map›Paper›PMID 41985455›Full record

ArticleCell reports. Medicine2026

Dual-targeted microspheres reshape the metabolic-immune microenvironment to reverse post-embolization dilemmas in hepatocellular carcinoma.

Nan Jiang, Zifan Pei, Fei Gong, Weihao Yang, Jiachen Xu, Jie Cao, Xiaoxiao Pan, Bin Yu, Jian Shen, Zhi Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nan JiangDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Zifan PeiInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Fei GongInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Weihao YangDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Jiachen XuDepartment of Vascular Surgery and Interventional Radiology, The Fourth Affiliated Hospital of Soochow University, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215125, China.
Jie CaoInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Xiaoxiao PanInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Bin YuDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Jian ShenDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Zhi LiDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Binyan ZhongDepartment of Interventional Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310052, China.
Caifang NiDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: szncf@suda.edu.cn.
Liang ChengInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials & Devices, Soochow University, Suzhou 215123, China. Electronic address: lcheng2@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transarterial embolization (TAE) efficacy in hepatocellular carcinoma (HCC) is limited by post-embolization hypoxia-driven angiogenesis and metabolic reprogramming. To address this, we develop pH-responsive gelatin microspheres (GMs) encapsulating zinc sulfide (ZnS) nanoparticles (ZnS-encapsulated gelatin microspheres [ZnS@GMs]) for the dual delivery of hydrogen sulfide (H

Indexed as

Carcinoma, HepatocellularEmbolization, TherapeuticLiver NeoplasmsMicrospheresTumor MicroenvironmentAnimalsCell Line, TumorGelatinHumansHypoxia-Inducible Factor 1, alpha SubunitNanoparticlesNeovascularization, PathologicRabbitsSulfidesGelatinHypoxia-Inducible Factor 1, alpha SubunitSulfidesangiogenesisembolic microspheresgas therapyglycolysistransarterial embolization therapy

Identifiers

PMID41985455
PMCPMC13198291

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.