Evidence map›Paper›PMID 41985672›Full record

ArticleMolecular metabolism2026

BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics.

Shirine E Usmani, Jean-Philippe Leduc-Gaudet, Stephanie Chau, Catherine A Bellissimo, Shabana Vohra, Krystel Desjardins, Evan Pollock-Tahiri, Irisa Shi, Felice Chun, Anthony Capobianco and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Shirine E UsmaniUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada; Division of Endocrinology & Metabolism, Department of Medicine, University Health Network, Toronto, ON, Canada.
Jean-Philippe Leduc-GaudetResearch Group in Cellular Signaling, Department of Medical Biology, Université du Québec À Trois-Rivières, Trois-Rivières, QC, Canada; Département des sciences de l'activité physique, Faculté des sciences, Université du Québec à Montréal, Montréal, QC, Canada; Groupe de Recherche en Activité Physique Adaptée, Faculté des Sciences, Université du Québec À Montréal, Montréal, Qc, Canada. Electronic address: Jean-Philippe.Leduc.Gaudet@uqtr.ca.
Stephanie ChauUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.
Catherine A BellissimoUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada.
Shabana VohraSchroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Krystel DesjardinsDépartement des sciences de l'activité physique, Faculté des sciences, Université du Québec à Montréal, Montréal, QC, Canada.
Evan Pollock-TahiriUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada.
Irisa ShiUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada.
Felice ChunUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada; Division of Endocrinology & Metabolism, Department of Medicine, University Health Network, Toronto, ON, Canada.
Anthony CapobiancoResearch Group in Cellular Signaling, Department of Medical Biology, Université du Québec À Trois-Rivières, Trois-Rivières, QC, Canada.
Pascale DelisleResearch Group in Cellular Signaling, Department of Medical Biology, Université du Québec À Trois-Rivières, Trois-Rivières, QC, Canada.
Wanda DupebeResearch Group in Cellular Signaling, Department of Medical Biology, Université du Québec À Trois-Rivières, Trois-Rivières, QC, Canada.
Marina CefisDépartement des sciences de l'activité physique, Faculté des sciences, Université du Québec à Montréal, Montréal, QC, Canada; INSERM UMR1093-CAPS, Université de Bourgogne, UFR des Sciences de Santé, Dijon, France.
Vincent MarcangeliDépartement des sciences de l'activité physique, Faculté des sciences, Université du Québec à Montréal, Montréal, QC, Canada.
Martha GhebreselassieUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada.
Yu-Cheng LiangUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada.
Yasufumi SekiUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada.
Dominique MayakiMeakins-Christie Laboratories, Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.
Sabah HussainMeakins-Christie Laboratories, Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada.
Ewan GoligherUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine and Department of Physiology, University of Toronto, Toronto, ON, Canada; Division of Respirology, Department of Medicine, University Health Network, Toronto, ON, Canada.
Mohit KapoorSchroeder Arthritis Institute, University Health Network, Toronto, ON, Canada; Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.
Marius LockeFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Gilles GouspillouDépartement des sciences de l'activité physique, Faculté des sciences, Université du Québec à Montréal, Montréal, QC, Canada; Meakins-Christie Laboratories, Department of Medicine, Faculty of Medicine, McGill University, Montréal, QC, Canada; Groupe de Recherche en Activité Physique Adaptée, Faculté des Sciences, Université du Québec À Montréal, Montréal, Qc, Canada. Electronic address: Gouspillou.gilles@uqam.ca.
Minna WooUniversity Health Network Research Institute, University Health Network, Toronto, ON, Canada; Division of Endocrinology & Metabolism, Department of Medicine, University Health Network, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada; Banting and Best Diabetes Centre, University of Toronto, Canada. Electronic address: Minna.Woo@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptional repressor B cell lymphoma 6 (BCL6) is highly expressed in skeletal muscle. Although transcriptome-wide studies have shown BCL6 dysregulation in muscular dystrophies, investigations into its endogenous roles in muscle biology remain scarce. We therefore generated skeletal muscle-specific Bcl6 knockout (M-Bcl6 KO) mice and used adeno-associated virus to knockdown (KD) Bcl6 selectively in limb muscles of mice. In both models, Bcl6 deficiency led to reduced muscle mass and contractility. Single-nucleus RNA sequencing and biochemical analyses revealed upregulation of Socs2, and inhibition of the IGF1/AKT pathway. Mitochondrial respiration was significantly reduced in permeabilized myofibers upon Bcl6 KO and KD, and electron microscopy showed decreased mitochondrial density and altered morphology. Pathways regulating mitochondrial quality control were also downregulated. While Bcl6 KO did not significantly impair baseline treadmill running capacity, it blunted the adaptive response to endurance training. These findings demonstrate that Bcl6 is a critical regulator of skeletal muscle mass and mitochondrial bioenergetics, acting through transcriptional control of signaling and metabolic pathways essential for the maintenance of muscle mass and function.

Indexed as

Energy MetabolismMitochondriaMitochondria, MuscleMuscle, SkeletalProto-Oncogene Proteins c-bcl-6AnimalsMaleMiceMice, KnockoutSignal TransductionSuppressor of Cytokine Signaling ProteinsBcl6 protein, mouseProto-Oncogene Proteins c-bcl-6Socs2 protein, mouseSuppressor of Cytokine Signaling ProteinsEndurance trainingMitochondriaMuscle atrophyOxidative phosphorylationRespirationSkeletal muscle

Identifiers

PMID41985672
PMCPMC13141646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.