Evidence map›Paper›PMID 41985702›Full record

ArticleBone2026

Prevalent vertebral fracture (PVFx) and abdominal aortic calcification (AAC) independently predict incident atherosclerotic cardiovascular disease (ASCVD) events in older men.

John T Schousboe, Joshua R Lewis, Lisa Langsetmo, Afsah Saleem, S Zulqarnain Gilani, Zaid Ilyas, Pawel Szulc, William D Leslie, Kristine E Ensrud

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John T SchousboeResearch & Evaluation Division, HealthPartners Institute, Bloomington, MN, USA; University of Minnesota, Minneapolis, MN, USA. Electronic address: scho0600@umn.edu.
Joshua R LewisNutrition & Health Innovation Research Institute, Edith Cowan University, Perth, Australia; Medical School, the University of Western Australia, Perth, Australia.
Lisa LangsetmoUniversity of Minnesota, Minneapolis, MN, USA; VA Medical Center, Minneapolis, MN, USA.
Afsah SaleemNutrition & Health Innovation Research Institute, Edith Cowan University, Perth, Australia; Centre for AI&ML, School of Science, Edith Cowan University, Perth, Australia.
S Zulqarnain GilaniNutrition & Health Innovation Research Institute, Edith Cowan University, Perth, Australia; Centre for AI&ML, School of Science, Edith Cowan University, Perth, Australia.
Zaid IlyasNutrition & Health Innovation Research Institute, Edith Cowan University, Perth, Australia; Centre for AI&ML, School of Science, Edith Cowan University, Perth, Australia.
Pawel SzulcINSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Lyon, France.
William D LeslieDepartments of Medicine and Radiology, University of Manitoba, Winnipeg, Canada.
Kristine E EnsrudUniversity of Minnesota, Minneapolis, MN, USA; VA Medical Center, Minneapolis, MN, USA.

Funding

Outcomes of Sleep Disorders in Older MenR01HL071194 · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 2003 to 2005
$1.5M
NHLBI NIH HHS R01 HL071194NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042145
6 · The paper itself

Abstract

purposeTo estimate the associations of prevalent vertebral fracture (PVFx) and abdominal aortic calcification (AAC) with incident ASCVD (myocardial infarction, fatal or non-fatal cerebrovascular accident, or coronary heart disease death).

methods2799 older men (mean [SD] age 76.3 [5.5] years) enrolled in the MrOS sleep ancillary study had PVFx (SQ grade 2 or 3) assessed by human reader and AAC by automated convolutional neural networks on baseline lateral spine radiographs. Auto-AAC was categorized as low, moderate, or high (24-point scale score < 2, 2 to <6, or ≥ 6). Men were contacted every 4 months for ascertainment of possible ASCVD events over a mean (SD) follow-up of 8.4 (3.1) years. Associations of PVFx and auto-AAC category with incident ASCVD were estimated with modified proportional hazards models accounting for non-CVD mortality.

resultsPVFx was present in 7.3% of the cohort; 34.5% had moderate auto-AAC, 28.8% had high auto-AAC, and 396 (14.1%) had an incident ASCVD event. Compared to men with low auto-AAC, those with moderate (HR 1.34, 95% CI 1.01, 1.77) and high (HR 1.55, 95% CI 1.16, 2.06) auto-AAC had increased risk of ASCVD events adjusted for PVFx and other risk factors. Compared to men with no PVFx, those with PVFx had a higher risk of ASCVD events (HR 1.51, 95% CI 1.07, 2.14) adjusted for auto-AAC level and other risk factors.

conclusionAAC assessed by automated methods and PVFx are independently associated with incident ASCVD events and may aid in ASCVD risk stratification in older men, but confirmatory studies are needed.

Indexed as

Aorta, AbdominalAortic DiseasesAtherosclerosisCalcinosisSpinal FracturesAgedHumansIncidenceMalePrevalenceRisk FactorsAACAbdominal aortic calcificationASCVDAtherosclerotic cardiovascular diseaseMACEMajor adverse cardiovascular eventsVertebral fracture

Identifiers

PMID41985702
PMCPMC13435188

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.