Evidence map›Paper›PMID 41986248›Full record

ReviewAnnals of medicine2026

Direct neuronal reprogramming: emerging therapeutic strategies for neurodegenerative disorders.

Arooja Tyagi, Vijendra Prabhu, Prasoon Agarwal, Praveen Kumar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arooja TyagiManipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.ORCID 0009-0007-5964-9962
Vijendra PrabhuManipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0001-5927-2180
Prasoon AgarwalNational Bioinformatics Infrastructure Sweden (NBIS), SciLifeLab, Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.ORCID 0000-0003-1813-7606
Praveen KumarManipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0002-6330-7355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment of brain injuries and neurodegenerative disorders is a critical challenge due to poor regenerative capabilities of the central nervous system. The current therapeutic strategies are primarily focussed on treating the symptoms than addressing the core issue of loss of neurons. Despite advances in stem cell therapies and surgical alternatives, they are not always successful due to challenges like immune rejection and limited efficacy. Direct neuronal reprogramming of endogenous somatic cells is a promising approach to restore lost neurons. This review evaluates traditional reprogramming techniques and their limitations, explores novel DISCUSSION: Traditional neuronal reprogramming is based on

conclusionsDirect neuronal reprogramming offers a viable strategy for replenishing neuronal cell mass in neurodegenerative diseases and brain injuries through autologous therapy. Novel

Indexed as

Cellular ReprogrammingCellular Reprogramming TechniquesNeurodegenerative DiseasesNeuronsAnimalsGenetic TherapyGene Transfer TechniquesHumansautologous therapyCell plasticityCRISPRpersonalised medicinesmall moleculestransdifferentiation

Identifiers

PMID41986248
PMCPMC13084837

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.