Evidence map›Paper›PMID 41986300›Full record

ArticleNature communications2026

ATP synthase is a promising target for identifying activated and non-activated adipose tissues.

Caitlin V M L Jie, Aro Delparente, Tongtong Wang, Lisa Reichert, Petra Krajnovic, Marc Schläppi, Lukas Reininger, Laura T L Brandt, Claudia Keller, Julien Orts and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Caitlin V M L Jie *Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0003-2894-5260
Aro Delparente *Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.
Tongtong WangDepartment of Health Sciences and Technology, Laboratory of Translational Nutrition Biology, ETH Zürich, Schwerzenbach, Switzerland.
Lisa ReichertDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-4684-8483
Petra KrajnovicDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.
Marc SchläppiDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-9979-6381
Lukas ReiningerDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0009-0008-0054-5752
Laura T L BrandtDepartment of Biology, Institute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0003-1830-4128
Claudia KellerDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.
Julien OrtsDepartment of Chemistry and Applied Biosciences, Institute for Molecular Physical Sciences, ETH Zürich, Zürich, Switzerland.
Roland RiekDepartment of Chemistry and Applied Biosciences, Institute for Molecular Physical Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-6333-066X
Stefanie D KrämerDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-0426-4340
Markus StoffelDepartment of Biology, Institute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0003-1304-5817
Christian WolfrumDepartment of Health Sciences and Technology, Laboratory of Translational Nutrition Biology, ETH Zürich, Schwerzenbach, Switzerland.ORCID http://orcid.org/0000-0002-3862-6805
Roger SchibliDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-1537-3833
Linjing MuDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland. linjing.mu@pharma.ethz.ch.ORCID http://orcid.org/0000-0001-5354-1546

Funding

Novartis Stiftung für Medizinisch-Biologische Forschung (Novartis Foundation for Medical-Biological Research) #22A047Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 205321_192409/1
6 · The paper itself

Abstract

Adipose tissue has gained increasing attention as a therapeutic target to combat human obesity and related metabolic disorders. We propose ATP synthase as a target to identify activated and non-activated adipose tissue. We investigated ATP synthase using the radiotracer [

Indexed as

Adipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteMitochondrial Proton-Translocating ATPasesAdrenergic beta-3 Receptor AgonistsAnimalsAutoradiographyCarbon RadioisotopesFluorodeoxyglucose F18HumansMaleMiceMice, Inbred C57BLPositron-Emission TomographyRadiopharmaceuticalsTissue DistributionAdrenergic beta-3 Receptor AgonistsCarbon RadioisotopesFluorodeoxyglucose F18Mitochondrial Proton-Translocating ATPasesRadiopharmaceuticals

Identifiers

PMID41986300
PMCPMC13260929

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.