ArticleCell discovery2026
Structural insights into the gating mechanism of the fission yeast phosphate exporter SpXpr1.
Article in Cell discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The PHO1 protein family in phosphate export and beyond.Plant physiology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Phosphate homeostasis is essential for fundamental cellular processes, including energy metabolism, signal transduction, and nucleic acid synthesis. Although XPR1 family proteins are conserved phosphate exporters throughout eukaryotes, their structural mechanisms in organisms other than mammals and plants remain largely unexplored. Here, we presented high-resolution cryo-electron microscopy (cryo-EM) structures of Schizosaccharomyces pombe Xpr1 (SpXpr1) in both the apo and inositol hexakisphosphate (InsP6)-bound states. While SpXpr1 shares conserved phosphate coordination sites with its human and plant orthologs, SpXpr1 employs a unique dual gating mechanism: (1) an intracellular gate formed by the N-loop of the SPX domain, stabilized by a preceding N-helix and an extended TM10 helix and (2) an extracellular ECL
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.