Evidence map›Paper›PMID 41986308›Full record

ArticleTranslational psychiatry2026

Stress and synaptic density in psychosis and clinical high risk: evidence from [

M Belen Blasco, Kankana Nisha Aji, Christian Ramos-Jiménez, Daniel Chartrand, Chris Hung-Hsin Hsiao, Robert Hopewell, Gassan Massarweh, Johan Cohen, Pablo M Rusjan, Romina Mizrahi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M Belen BlascoIntegrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
Kankana Nisha AjiClinical and Translational Sciences Lab, Douglas Research Centre, Montreal, QC, Canada.
Christian Ramos-JiménezIntegrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
Daniel ChartrandDepartment of Anesthesia, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-3397-578X
Chris Hung-Hsin HsiaoMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Robert HopewellMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Gassan MassarwehMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Johan CohenDouglas Mental Health University Institute, McGill University, Verdun, QC, Canada.
Pablo M RusjanClinical and Translational Sciences Lab, Douglas Research Centre, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-0075-2918
Romina MizrahiClinical and Translational Sciences Lab, Douglas Research Centre, Montreal, QC, Canada. romina.mizrahi@mcgill.ca.ORCID http://orcid.org/0000-0001-6667-7928

Funding

Fonds de Recherche du Québec-Société et Culture (FRQSC) 348199Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre) APP400704
6 · The paper itself

Abstract

Synaptic dysfunction is implicated in the pathophysiology of schizophrenia, and positron emission tomography (PET) studies demonstrate in vivo reductions in synaptic density across illness stages. Stress is a key modifiable risk factor, and while animal studies show it disrupts synaptic function, its effects on humans remain unclear. We examined the relationship between stress and synaptic density in individuals with first-episode psychosis (FEP) and those at clinical high risk (CHR). Seventy-eight participants, including 25 FEP, 32 CHR, and 21 healthy controls (HC), underwent 90-min [

Indexed as

BrainPsychotic DisordersStress, PsychologicalSynapsesAdolescentAdultDepressionFemaleFluorine RadioisotopesHumansMalePositron-Emission TomographyPyridinesPyrrolidinesRadiopharmaceuticalsYoung AdultFluorine RadioisotopesPyridinesPyrrolidinesRadiopharmaceuticalsSynVesT-1

Identifiers

PMID41986308
PMCPMC13194929

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.