Evidence map›Paper›PMID 41986309›Full record

ArticleCell death & disease2026

Effect of the cardiac long non-coding RNA Charme depletion on the maturation and paracrine signaling of resident cardiac fibroblasts.

Erica Floris, Claudia Cozzolino, Giulia Buonaiuto, Valeria Taliani, Antonella Bordin, Alessandro Palma, Vittorio Picchio, Xhulio Dhori, Francesco Nutile, Carmine Nicoletti and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Erica FlorisDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.ORCID http://orcid.org/0000-0002-8012-4681
Claudia CozzolinoDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.ORCID http://orcid.org/0000-0002-8921-6267
Giulia BuonaiutoDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Valeria TalianiEMBL, Genome Biology Unit, Heidelberg, Germany.
Antonella BordinDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Alessandro PalmaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0003-1300-5479
Vittorio PicchioDepartment of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.ORCID http://orcid.org/0000-0003-1591-5118
Xhulio DhoriCINECA, Super Computing Applications and Innovation Department, Rome, Italy.ORCID http://orcid.org/0009-0008-7556-8342
Francesco NutileDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Carmine NicolettiDAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-5896-2040
Giacomo FratiDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Monica Ballarino *Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy. monica.ballarino@uniroma1.it.ORCID http://orcid.org/0000-0002-8595-7105
Isotta Chimenti *Department of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy. isotta.chimenti@uniroma1.it.ORCID http://orcid.org/0000-0002-0865-8814
Francesca Pagano *Institute of Biochemistry and Cell Biology, National Council of Research (IBBC-CNR), Monterotondo, Italy. francesca.pagano@cnr.it.ORCID http://orcid.org/0000-0003-1956-5864

Funding

Sapienza Università di Roma (Sapienza University of Rome) AR12218167E8FA71Sapienza Università di Roma (Sapienza University of Rome) AR223188B40CB2D0Sapienza Università di Roma (Sapienza University of Rome) RM12117A5DE7A45BSapienza Università di Roma (Sapienza University of Rome) RM123188F6B80CE4
6 · The paper itself

Abstract

Charme is a murine long non-coding RNA necessary for the embryonic development of the heart. In vivo Charme knock-out causes prominent alterations of tissue structure, due to cardiac hyperplasia, and leads to the development of cardiac dysfunctions. Cardiac fibroblasts (CFs) play pivotal roles in both the development and homeostatic maintenance of the cardiac tissue, and the effect of Charme depletion on this cell compartment has not been addressed. This study investigated the phenotype and function of resident CFs isolated from Charme knockout (Charme

Indexed as

FibroblastsMyocardiumParacrine CommunicationRNA, Long NoncodingAnimalsCell DifferentiationExtracellular MatrixMiceMice, KnockoutMyocytes, CardiacMyofibroblastsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Long Noncoding

Identifiers

PMID41986309
PMCPMC13201650

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.