Evidence map›Paper›PMID 41986319›Full record

ReviewNature communications2026

Decoding immunotherapy response through computational modeling.

Bingrui Li, Ruihan Luo, Kexin Huang, Jiajia Liu, Weiling Zhao, Xiaobo Zhou

Abstract readReview
In one paragraph

Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bingrui Li *Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ruihan Luo *Center for Computational Systems Medicine, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5997-4051
Kexin Huang *Center for Computational Systems Medicine, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jiajia LiuCenter for Computational Systems Medicine, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Weiling ZhaoCenter for Computational Systems Medicine, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Xiaobo ZhouCenter for Computational Systems Medicine, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA. Xiaobo.Zhou@uth.tmc.edu.ORCID http://orcid.org/0000-0001-7191-6495

Funding

Multiscale Resolution and Deep Network Approaches for Deconvolving Different Cell Types in Bulk Tumor using Single-cell Sequencing Data (scDEC)R01CA241930 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, XIAOBO · 2019 to 2023
$2.7M
Microbial-based platform for assessing organ damage in alcohol use disorders (AUD)R01AA032723 · NIAAA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Faraz Bishehsari, Xiaobo Zhou · 2025 to 2026
$1.2M
Optimizing mRNA sequences with deep neural networksR01LM014156 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Xiaobo Zhou · 2024 to 2026
$1.1M
Developing mRNAdesigner tool package for optimization of mRNA sequenceR01GM153822 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, XIAOBO · 2024 to 2025
$624k
NCI NIH HHS R01 CA241930NIAAA NIH HHS R01 AA032723NIGMS NIH HHS R01 GM153822NLM NIH HHS R01 LM014156U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AA032723U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA241930U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM153822U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01LM014156
6 · The paper itself

Abstract

Immunotherapy has seen success in treating patients with cancer, but variable responses underscore the need for effective patient stratification and therapy planning. Computational tools integrating multi-omics, imaging and machine learning have advanced, yet reliable personalized predictions remain challenging. This review analyzes the field through four converging paradigms: classical machine learning, deep learning, graph and network modeling, and mechanistic systems biology. We examine the evolution from correlational features to representation learning, relational inference, and causal simulation of tumor-immune dynamics, highlighting the shift towards multi-modal fusion and interpretable, clinically deployable models. By providing an integrated review of these computational tools, we hope to bring the community closer to achieving precision immuno-oncology for personalized cancer treatments.

Indexed as

ImmunotherapyNeoplasmsComputer SimulationHumansImmunoinformaticsMachine LearningPrecision MedicineSoft ComputingSystems Biology

Identifiers

PMID41986319
PMCPMC13260445

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.