Evidence map›Paper›PMID 41986365›Full record

ArticleNPJ systems biology and applications2026

Revealing novel subtypes of synovial sarcoma through single cell transcriptomics.

Artem L Toropov, Elena E Kopantseva, Alexander V Ikonnikov, Maxim E Menyailo, Timur I Fetisov, Anna M Stroganova, Daria A Meshkova, Nikolay A Kozlov, Polina A Shtompel, Sofya A Khazanova and 5 more

Abstract read
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In one paragraph

Article in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Artem L Toropov *Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Elena E Kopantseva *Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Alexander V IkonnikovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Maxim E MenyailoResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Timur I FetisovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Anna M StroganovaN.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Daria A MeshkovaN.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Nikolay A KozlovN.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Polina A ShtompelN.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Sofya A KhazanovaN.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Ekaterina A TrapeznikovaN.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Kirill I KirsanovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Anastasia A TararykovaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Marianna G YakubovskayaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Evgeny V DenisovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia. denisov-ev@rudn.ru.

Funding

Russian Scientific Foundation Grant #23-65-00003
6 · The paper itself

Abstract

Synovial sarcoma (SyS) is a common type of soft tissue sarcoma, characterized by slow growth, high rates of metastasis, and diverse clinical symptoms. This malignancy is defined by the presence of the SS18-SSX fusion protein and the corresponding SS18-SSX program that promotes the core oncogenic pathways and a wide spectrum of tumor cell phenotypes. In this study, we used single-cell RNA sequencing to explore SyS diversity, highlighting four molecular subtypes. The mesenchymal NKD2

Indexed as

Sarcoma, SynovialSingle-Cell AnalysisTranscriptomeCell DifferentiationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansOncogene Proteins, FusionSingle-Cell Gene Expression AnalysisOncogene Proteins, Fusion

Identifiers

PMID41986365
PMCPMC13442865

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.