Evidence map›Paper›PMID 41986718›Full record

ArticleNature2026

Cell-type-targeted mitochondrial transplantation rescues cell degeneration.

Temurkhan Ayupov, Verónica Moreno-Juan, Serena Curtoni, Alex Fratzl, Upnishad Sharma, Susana Posada-Céspedes, Ramona Ratiu, Rei Morikawa, Alexandra Graff Meyer, Margherita Pezzoli and 19 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Temurkhan Ayupov *Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-3009-0030
Verónica Moreno-Juan *Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-2529-8408
Serena CurtoniInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Alex FratzlInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-4064-0742
Upnishad SharmaDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Susana Posada-CéspedesInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-7459-8186
Ramona RatiuInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Rei MorikawaInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Alexandra Graff MeyerFacility for Advanced Imaging and Microscopy, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0001-9312-9230
Margherita PezzoliImmunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0002-1705-0082
Glenn BantugImmunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-2253-6028
Morgan ChevalierInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0007-2111-7389
Yanyan HouInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Sarah A NadeauInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Álvaro Herrero-NavarroInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0001-9385-9727
Vikram AyinampudiInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Elizabeth KastanakiInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Natasha WhiteheadInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Rebecca A SiwickiInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-2061-3782
Mariana M RibeiroInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-4808-6643
Ji Hoon HanInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Annalisa BucciInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-6955-2204
Christoph HessImmunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0364-8825
Simone PicelliInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1747-614X
Magdalena RennerInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Daniel J MüllerDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID http://orcid.org/0000-0003-3075-0665
Cameron S CowanInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-4262-1182
Simon HansenInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Botond RoskaInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland. botond.roska@iob.ch.ORCID http://orcid.org/0000-0002-9559-1450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of currently untreatable diseases, including neurodegenerative disorders, optic nerve atrophy and heart failure, are associated with mitochondrial dysfunction. Transplantation of healthy mitochondria has been proposed as a potential therapeutic strategy

Indexed as

MitochondriaAnimalsCytosolEndothelial CellsFemaleHumansMaleMiceMice, Inbred C57BLMitochondrial DynamicsNeuronsRetina

Identifiers

PMID41986718
PMCPMC13149334

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.