ArticleMolecular psychiatry2026
Postpartum psychosis is associated with elevated neuromelanin-MRI signal in the midbrain.
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
objectivePostpartum psychosis (PP) is an uncommon psychiatric condition that, if untreated, can have devastating consequences. The underlying biology of PP remains poorly understood. To investigate the neurobiological mechanisms of PP, this study measured neuromelanin (NM)-sensitive magnetic resonance imaging (MRI) signal intensity, a marker of dopamine turnover, in the midbrain of women with a prior history of PP (n = 30) and a group of demographically-matched healthy control (HC) women (n = 24).
methodsNM-MRI signal intensity in dopamine-rich midbrain areas, the substantia nigra (SN) and ventral tegmentum area (VTA), as well as whole-brain resting-state functional connectivity of the bilateral SN, were measured and compared across the two groups.
resultsSignificantly elevated levels of NM-MRI signal in the SN and VTA were observed in the PP (vs. the HC) group, and these elevations were significantly correlated with levels of residual, subclinical psychotic symptoms within the PP group. Additionally, significant decreases were observed in the PP (vs HC) group in the functional connectivity of the bilateral SN to multiple subcortical regions; these decreases were associated with levels of SN NM-MRI signal and subclinical psychotic symptoms.
conclusionsThis study provides the first evidence for elevated midbrain NM-MRI signal in women with a history of PP. Also, this abnormality was linked to the presence of residual subclinical psychotic symptoms and altered connectivity of the SN. Future studies will determine whether NM-MRI can serve as a useful tool for screening women for risk for PP.
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