Evidence map›Paper›PMID 41986768›Full record

ArticleIn vitro cellular & developmental biology. Animal2026

Oncogenic role and potential mechanisms of MYO1B in breast cancer.

Mei Dai, Qin Jiang, Danhua Zhang, Lun Li

Abstract read
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In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mei DaiDepartment of General Surgery, Second Xiangya Hospital, Central South University, Danhua Zhang, No. 139 Middle People Road, Changsha, 410011, Hunan, China.
Qin JiangDepartment of General Surgery, Second Xiangya Hospital, Central South University, Danhua Zhang, No. 139 Middle People Road, Changsha, 410011, Hunan, China.
Danhua ZhangDepartment of General Surgery, Second Xiangya Hospital, Central South University, Danhua Zhang, No. 139 Middle People Road, Changsha, 410011, Hunan, China. zhangdanhua@csu.edu.cn.ORCID http://orcid.org/0000-0002-0586-4284
Lun LiDepartment of General Surgery, Second Xiangya Hospital, Central South University, Danhua Zhang, No. 139 Middle People Road, Changsha, 410011, Hunan, China. lilun6830@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myosin IB (MYO1B), a member of the type I myosin family, is overexpressed in various tumor tissues. MYO1B facilitates tumor progression by regulating cellular proliferation, migration, and the epithelial-mesenchymal transition (EMT). However, the precise function of MYO1B in breast cancer (BRCA) is still not well understood. We analyzed MYO1B expression, prognostic significance, immune infiltration, and its correlation with drug resistance in BRCA using meta-analysis and public databases. Functional assays in BRCA cells were performed to evaluate the effects of MYO1B on cell proliferation, apoptosis, and sensitivity to tamoxifen and palbociclib. MYO1B mRNA levels showed no significant difference between BRCA and normal tissues, whereas MYO1B protein was upregulated in tumor tissues. High MYO1B expression was associated with poor prognosis in BRCA patients. Functionally, MYO1B promoted BRCA cell proliferation, inhibited apoptosis, and increased resistance to tamoxifen and palbociclib. Mechanistically, MYO1B activated the Pi3k-AKT signaling pathway. Our study suggests that MYO1B promotes the progression of BRCA and may serve as a new target for overcoming endocrine therapy resistance.

Indexed as

Breast NeoplasmsCarcinogenesisMyosin Type IOncogenesApoptosisCell Line, TumorCell MovementCell ProliferationDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansPhosphatidylinositol 3-KinasesPrognosisProto-Oncogene Proteins c-aktSignal TransductionMYO1B protein, humanMyosin Type IPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTamoxifenBreast cancerDrug resistanceMYO1BOncogenesisPrognosis

Identifiers

PMID41986768

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.