ArticleAnimal bioscience2026
Dietary supplementation of Platycodon grandiflorum polysaccharides mitigates weaning stress in piglets by modulating intestinal microbiota and improving gut health.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Platycodon grandiflorum and Glycyrrhiza uralensis extract attenuates cyclophosphamide-induced tracheal mucosal barrier injury in broilers by modulating gut microbiota and short-chain fatty acids.Poultry science · 2026Article
- High-Resolution Mass Spectrometry Reveals Distinct Temporal Accumulation Patterns of Metabolites in Reproductive Organs of Purple- and White-FloweredLife (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivePlatycodon grandiflorum polysaccharide (PGP) extracted from Platycodon grandiflorum, which has the advantages of anti-inflammatory, antioxidant, anti-tumor, and no side effects on the organism. This study evaluated whether dietary PGP alleviates weaning-induced intestinal dysfunction in piglets.
methodsA total of 18 newly weaned piglets (6.46±0.31 kg) were allocated to 3 treatments (n = 6/group) for a 28-day feeding trial. The control group received a basal diet, while the L-PGP and H-PGP groups were supplemented with 1 g/kg and 2 g/kg PGP, respectively. On day 28, piglets were electrically stunned and euthanized by exsanguination; spleen, liver, and colon samples were collected to assess inflammatory/antioxidant markers, barrierrelated genes, and colonic microbiota.
resultsThe supplementation of PGP increased the average daily gain (p<0.05), and reduced the feed-to-gain ratio of weaned piglets. In addition, PGP reduced the expression of splenic IL-1β, IL-2, and IL-4 (p<0.05). This effect was associated with upregulated mRNA levels of the key tight junction proteins Occludin, ZO‑1, and Claudin‑1 in the colonic mucosa and tissue (p<0.05). Compared with the control group, the mRNA expression levels of PKC, Nrf2 and KEAP1 in the colonic tissue of weaned piglets were increased in the HPGP (p<0.05). More importantly, H-PGP supplementation increased the relative abundances of Bacteroidota, while decreasing the abundance of Proteobacteria. Moreover, Spearman correlation analysis revealed that short-chain fatty acid-producing commensal genera (Faecalibacterium) were negatively correlated with pro-inflammatory cytokines and signaling genes, but positively correlated with antioxidant genes (p<0.05). Conversely, the relative abundance of Escherichia-Shigella was negatively correlated with the mRNA expression of PKC, Nrf2, and Keap1 (p<0.05).
conclusionPGP can alleviate the weaning stress in piglets, by modulating the colonic microbiota and enhancing systemic anti-inflammatory capacity and intestinal barrier function.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.