ArticleBMC pregnancy and childbirth2026
Altered Notch pathway-related protein expression in cord blood of preeclampsia offspring: a pilot study.
Article in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to test the hypothesis that the NCOR2/DLL-4/Jagged-1 axis is dysregulated in cord blood of offspring from mothers with preeclampsia (PE) and gestational hypertension (GH), favoring an anti-angiogenic profile. We compared expression levels of these Notch pathway components among PE, GH, and healthy control groups to explore their potential role in fetal vascular programming.
methodsThis is a prospective cohort study, including 17 mother-offspring pairs with gestational hypertension, 17 mother-offspring pairs with preeclampsia, and 34 healthy mother-offspring pairs as controls. Standardized questionnaires were used to collect family and birth information, medical records were used to collect clinical data, and Western blot was employed to measure the expression levels of NCOR2, DLL-4, and Jagged-1 in cord blood. We analyzed the differences in offspring cord blood proteins among the three groups.
resultsCord blood protein expression revealed significant dysregulation of the NCOR2/DLL-4/Jagged-1 axis. Compared to the control group (1.36 ± 0.44), the GH (1.00 ± 0.12) and PE (0.94 ± 0.15) groups were characterized by a significant downregulation of NCOR2 (p = 0.001). Furthermore, a progressive and significant increase in DLL-4 (p = 0.001) was observed across the control (0.82 ± 0.28), GH (0.98 ± 0.17), and PE (1.27 ± 0.40) groups, which was accompanied by a significant stepwise decrease in Jagged-1 expression (control: 1.36 ± 0.28, GH: 1.02 ± 0.12, PE: 0.87 ± 0.18, p < 0.001).
conclusionThe cord blood levels of NCOR2 and Jagged-1 proteins were significantly decreased in offspring of PE and GH, while DLL-4 protein expression was significantly increased in offspring of PE. These findings suggest that dysregulated Notch signaling, characterized by an anti-angiogenic profile in the fetal circulation, may contribute to the vascular programming observed in offspring of preeclamptic pregnancies.
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