SynthesisNutrition journal2026
Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.
Synthesis in Nutrition journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundResveratrol has shown health benefits like anti-obesity, antioxidant, and anti-inflammatory effects.
objectivesTo resolve conflicting findings and clarify its impact, our study summarizes resveratrol supplementation’s effects and evaluates its effectiveness across populations.
methodsWe conducted the search through PubMed, Embase, and Web of Science databases from inception to April 30th, 2025, to identify meta-analyses of randomized controlled trials examining the effects of resveratrol supplementation on human health. The quality of included studies was evaluated using the A Measurement Tool to Assess Systematic Reviews (AMSTAR) tool, and the credibility of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. This study was registered in PROSPERO (CRD 42024554480).
resultsForty-five systematic reviews with 129 associations between resveratrol supplementation and human health were included, which consists of 68 outcomes. Using the AMSTAR measurement tool, all articles were categorized as moderate-to-high quality. Among 35 significant associations, four were supported by high-certainty evidence according to GRADE, including positive effects of resveratrol supplementation on reducing waist circumference (mean difference [MD] = -0.80 cm, 95% CI = -1.40, -0.20), total cholesterol among overweight adults (MD = -0.19 mmol/L, 95% CI = -0.32, -0.06), diastolic blood pressure (MD = -3.55 mmHg, 95% CI = -5.18, -1.93) and systolic blood pressure (MD = -7.97 mmHg, 95% CI = -10.63, -5.31) among patients with type 2 diabetes. Moreover, moderate-certainty evidence indicated that resveratrol supplementation may promote glucose metabolism, improve renal function, protect endothelial health, enhance working memory, improve hepatic steatosis, lower hormones, and reduce inflammation.
conclusionsHigh certainty of evidence suggested that resveratrol supplementation could decline waist circumference, lower blood pressure among patients with type 2 diabetes, and reduce total cholesterol among overweight adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.