ArticleDatabase : the journal of biological databases and curation2026
TCMToxDB: a comprehensive database for the toxicological analysis of traditional Chinese medicines.
Article in Database : the journal of biological databases and curation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
The safety and modernization of traditional Chinese medicine (TCM) are significant concerns for human beings. Recently, the adverse effects caused by the use of certain TCMs have been frequently reported. Although TCMs may cause toxic reactions, they also play critical roles in treating multiple complex diseases. Therefore, toxicity research is urgently needed for the safe usage of TCMs. However, existing databases for TCMs primarily focus on the pharmacological effects of TCMs, with limited attention to the toxicity. They neither distinguish the toxic effects of formulas, herbs, and ingredients, nor classify and summarize targets for specific toxic manifestations, or assemble evidence from previous studies. We developed TCMToxDB, a comprehensive database that focuses on the toxicity and safe usage of TCMs. TCMToxDB systematically integrates and analyses the research results of toxic TCMs, offering users diverse information acquisition and analysis services. In addition, it assembles five canonical herb-target and ingredient-target interaction prediction algorithms with different advantages, which support the prediction of toxic targets of herbs and ingredients to empower the toxicity research of TCMs and to meet users' personal needs. TCMToxDB is accessible at https://www.sdu-idea.cn/TCMToxDB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.