Evidence map›Paper›PMID 41988321›Full record

ArticleJournal of thoracic disease2026

Quality of life after preoperative home-based exercise training in patients with lung cancer: a secondary analysis.

Sara Pimenta, Pedro Machado, Cândida G Silva, Ana Luís Garcia, Tiago Nogueira, Sónia Silva, Claúdia Lares Dos Santos, Maria Vitória Martins, André Canha, Bárbara Oliveiros and 2 more

Abstract read
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara PimentaCenter for Innovative Care and Health Technology (ciTechCare), Polytechnic University of Leiria, Leiria, Portugal.
Pedro MachadoCenter for Innovative Care and Health Technology (ciTechCare), Polytechnic University of Leiria, Leiria, Portugal.
Cândida G SilvaCenter for Innovative Care and Health Technology (ciTechCare), Polytechnic University of Leiria, Leiria, Portugal.
Ana Luís GarciaThoracic Surgery Unit, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal.
Tiago NogueiraThoracic Surgery Unit, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal.
Sónia SilvaPulmonology Department, Leiria Hospital Center, Leiria, Portugal.
Claúdia Lares Dos SantosPulmonology Department, Hospital Distrital de Santarém, Santarém, Portugal.
Maria Vitória MartinsPulmonology Department, Hospital Distrital da Figueira da Foz, Figueira da Foz, Portugal.
André CanhaPhysical Medicine and Rehabilitation Department, Hospital Distrital de Santarém, Santarém, Portugal.
Bárbara OliveirosLaboratory of Biostatistics and Medical Informatics (LBIM), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Raul A MartinsUniversity of Coimbra, Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, Coimbra, Portugal.
Joana CruzCenter for Innovative Care and Health Technology (ciTechCare), Polytechnic University of Leiria, Leiria, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A preoperative home-based exercise training (PHET) program appeared to improve health-related quality of life (HRQoL) in patients undergoing lung cancer surgery. However, inter-individual variability in response was observed. This secondary analysis aimed to identify characteristics of responders/non-responders to PHET, determine predictors of response, and examine whether preoperative HRQoL response to PHET is associated with postoperative HRQoL maintenance. Methods: This was a secondary analysis of pooled data from a feasibility study and a randomized controlled trial, including sociodemographic/clinical data, physical performance and HRQoL (EORTC-QLQ-C30). Responders/non-responders were classified based on a change of ≥5 points in Global QoL score (EORTC QLQ-C30) from baseline to pre-surgery time point. Between-group differences and predictors of PHET response (logistic regression) were analysed. Results: 32 patients (63% male, 67.1±7.8 years) were included, from which 56% (n=18) were responders to PHET in Global QoL. Responders had lower baseline scores in Global QoL, Emotional Function and Summary Score compared to non-responders (P<0.05), and 50% of responders had chronic obstructive pulmonary disease (COPD) (P=0.02). No other between-group differences were found (P>0.05). In the regression model including the Summary Score (EORTC-QLQ-C30) and COPD (Nagelkerke R2=0.511), COPD was a significant predictor of response: COPD patients were 13.4 times more likely to be responders (odds ratio =13.4; 95% confidence interval: 1.4; 132.2). 65% of PHET-responders maintained/improved HRQoL 1-month post-surgery. Conclusions: Most patients awaiting lung cancer surgery responded in HRQoL to a PHET, however, a considerable proportion did not. Further research is needed to identify characteristics of non-responders and optimize prehabilitation strategies accordingly.

Indexed as

health-related quality of life (HRQoL)lung cancerPrehabilitation

Identifiers

PMID41988321
PMCPMC13077382

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.