ArticleACS pharmacology & translational science2026
A Simple and Robust Microfluidic Glomerular Filtration Barrier-on-a-Chip Platform for Investigating Drug-Induced Nephrotoxicity.
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The glomerulus is the filtering unit of the kidney, and the glomerular filtration barrier (GFB) is responsible for filtering waste, retaining plasma protein, and maintaining fluid balance. Drug-induced nephrotoxicity is characterized by dysfunction of the GFB and is a main obstacle in the new therapeutic screening process. This paper presents the simple and robust SLAS (Society of Laboratory Automation and Society) standard format-based microfluidic GFB-on-a-chip (GFBoC). We formed and cultured the GFB by aligning human glomerular mesangial cells (gMCs), podocytes, and glomerular endothelial cells (gECs) on each side of a conventional transwell membrane as the glomerular basement membrane (GBM). This provides facile loading/unloading of the GFB transwell into the microfluidic chip, enabling its cultivation under pump-/tubing-less perfusion flow and additional off-chip bioanalysis. It also allows various and multiple experiments in parallel in a conventional incubator at moderate operation complexity. Glomerular selective permeability of the GFB was characterized by filtration and leakage of the representative macromolecule, albumin,
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