Evidence map›Paper›PMID 41988369›Full record

ReviewACS pharmacology & translational science2026

Exploring Galectin‑3 as an Emerging Frontier in Biomarker Research for Clinical Trials Approaching Cardiovascular Diseases.

Luís Perpétuo

Abstract readReview
In one paragraph

Review in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Luís PerpétuoiBiMED, Department of Medical Sciences, University of Aveiro, Campus Universitário de Santiago, Aveiro 3810-193, Portugal.ORCID https://orcid.org/0000-0002-8207-7700

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research has consistently highlighted galectin-3 (Gal-3) as a leading biomarker candidate for cardiovascular and cerebrovascular disease. Within studies focused on atherosclerosis-related cardiovascular disease, Gal-3 has played a multifaceted role, from monitoring disease progression to predicting outcomes. This reanalysis highlights the association of Gal-3 with various clinical factors, pathophysiological processes, other biomarkers, and critical outcomes. To maximize the potential of Gal-3 in future research, a uniform methodology that ensures consistent and easily comparable results is essential. Furthermore, our results highlight the synergy between elevated Gal-3 levels and established diagnostic measures of heart failure (HF). In this review, we present a reanalysis that provides a seminal synthesis of clinical trials using Gal-3 as a measure or outcome measure and aims to both capture current understanding and pave the way for its increased clinical application.

Indexed as

biomarkersclinical trialsgalectin-3heart failuremyocardial infarction

Identifiers

PMID41988369
PMCPMC13077495

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.