Evidence map›Paper›PMID 41988386›Full record

ReviewFrontiers in cell and developmental biology2026

Endogenous mediators in regulating primary dysmenorrhea.

Wenwen Duan, Yingtao Ma, Qinjian Dong, Quanwu Wang, Yijie Xie, Guangmei Liu, Chao Wang, Min He

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenwen Duan *Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Yingtao Ma *Department of Pediatrics, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
Qinjian DongDepartment of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Quanwu WangDepartment of Tuina, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
Yijie XieDepartment of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Guangmei LiuDepartment of Anus and Intestine Surgery, Maoming Hospital of Guangzhou University of Traditional Chinese Medicine, Maoming, Guangdong, China.
Chao WangSub-Health Department, Sichuan Integrative Medicine Hospital, Chengdu, Sichuan, China.
Min HeNortheast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary dysmenorrhea is currently an unresolved public health problem worldwide, which suffers the patients comprehensive symptoms. Currently, more and more studies have been focusing on biomarker exploration for diagnosis and target therapies of the primary dysmenorrhea. In this paper, we integrated and summarized the reported potential endogenous mediators of primary dysmenorrhea, which refer to endocrine mediators such as prostaglandins, vasopressin, estradiol, oxytocin, endothelin-1, etc., that contribute to inflammatory response and regulation of endometrial myometrial, vasoconstriction, as well as the onset of pain. With the help of current techniques, such as metabolomics (for,

Indexed as

antioxidantsendocrine hormonesendogenous mediatorsimmunomodulatory factorsneurotransmittersprimary dysmenorrhea

Identifiers

PMID41988386
PMCPMC13076572

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.