ArticleFrontiers in pharmacology2026
Wenyang Huazhuo formula extract ameliorates diabetic kidney disease in db/db mice and is associated with modulation of MHC class II molecules and gut microbiota.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The purpose of this study was to investigate the therapeutic effects and underlying mechanisms of Wenyang Huazhuo Formula (WYHZF) extract in diabetic kidney disease (DKD) in db/db mice. DKD mice were administered WYHZF extract by oral gavage, and glycolipid metabolism, renal function, and renal pathology were assessed. Renal histopathology was evaluated using H&E, PAS, and Masson's trichrome staining. UPLC-QE-Orbitrap-MS, HPLC, and UV-Vis spectroscopy were employed to characterize prototype and potential blood-absorbed metabolites of WYHZF extract. Renal RNA-seq was conducted to identify differentially expressed genes and related pathways. Molecular docking and molecular dynamics simulations were used as supportive
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