ArticleBiomaterials science2026
A click-crosslinked dopamine-functionalized hydrogel for therapeutic delivery of stem cell-derived extracellular vesicles.
Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Stem cell-derived extracellular vesicles (EVs) hold significant promise for tissue regeneration due to their potent therapeutic cargo. However, their clinical translation is hindered by rapid clearance from target sites following systemic or local administration, leading to inefficient delivery and limited therapeutic efficacy. To overcome this critical challenge, we developed a click-crosslinked dopamine-functionalized hyaluronic acid hydrogel system (Dopa-HA) for the sustained and localized delivery of EVs. Dopamine was chemically conjugated to the click-crosslinked hydrogel to enhance the robust immobilization of EVs. The physicochemical properties of this hydrogel system were subsequently characterized, including dopamine functionalization degree, rheological behavior, degradation rates, and
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