Evidence map›Paper›PMID 41989521›Full record

ReviewApoptosis : an international journal on programmed cell death2026

Relationship between different modes of death and premature ovarian insufficiency: a literature review.

Huihui Li, Ruotong Ju, Puhua Zhang, Chenyu Jia, Tingting Xue, Shu Wang, Xinyu Zhu, Ruixiang Zhu, Jiali Luo, Xuan Jing and 1 more

Abstract readReview
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In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huihui LiDepartment of Reproductive Medicine Center, Children's Hospital of Shanxi, The Affiliated Children's Hospital of Shanxi Medical University, Shanxi Maternal and Child Health Hospital, Taiyuan, 030001, China.
Ruotong JuDepartment of Reproductive Medicine Center, Children's Hospital of Shanxi, The Affiliated Children's Hospital of Shanxi Medical University, Shanxi Maternal and Child Health Hospital, Taiyuan, 030001, China.
Puhua ZhangDepartment of Reproductive Medicine Center, Children's Hospital of Shanxi, The Affiliated Children's Hospital of Shanxi Medical University, Shanxi Maternal and Child Health Hospital, Taiyuan, 030001, China.
Chenyu JiaDepartment of Reproductive Medicine Center, Children's Hospital of Shanxi, The Affiliated Children's Hospital of Shanxi Medical University, Shanxi Maternal and Child Health Hospital, Taiyuan, 030001, China.
Tingting XueDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, 030001, China.
Shu WangDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, 030001, China.
Xinyu ZhuDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, 030001, China.
Ruixiang ZhuDepartment of Reproductive Medicine Center, Children's Hospital of Shanxi, The Affiliated Children's Hospital of Shanxi Medical University, Shanxi Maternal and Child Health Hospital, Taiyuan, 030001, China.
Jiali LuoDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, 030001, China.
Xuan JingDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, 030001, China. jx05070103@163.com.
Xiangrong CuiDepartment of Reproductive Medicine Center, Children's Hospital of Shanxi, The Affiliated Children's Hospital of Shanxi Medical University, Shanxi Maternal and Child Health Hospital, Taiyuan, 030001, China. cuixiangrong094030@163.com.

Funding

Fundamental Research Program of Shanxi Province Grant no. 20240302121275Postgraduate Education Innovation Program of Shanxi Province Grant no. 2025SJ252Research Project Supported by Shanxi Scholarship Council of China Grant no. 2025-225The Scientific Research Project of Shanxi Provincial Health Commission Grant no.2025QM021
6 · The paper itself

Abstract

Early-onset ovarian insufficiency (POI) is a heterogeneous disorder characterized by complex etiology and the involvement of diverse programmed cell death modalities. This review aims to systematically elucidate the molecular mechanisms underlying programmed cell death in the pathogenesis of POI, with an emphasis on regulatory signaling networks and the dynamic switching of cell death modalities under distinct etiological contexts. We summarize the roles of key programmed cell death pathways-including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death-in the onset and progression of POI. In addition, potential therapeutic strategies targeting dysregulated cell death processes are briefly discussed.

Indexed as

ApoptosisPrimary Ovarian InsufficiencyAnimalsAutophagyFemaleFerroptosisHumansNecroptosisPyroptosisSignal TransductionApoptosisAutophagic cell death (ACD)Cell death interventionFerroptosisNecrosisPremature ovarian insufficiency (POI)Pyroptosis

Identifiers

PMID41989521

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.