Evidence map›Paper›PMID 41989749›Full record

ArticleObesity surgery2026

Prophylactic Tranexamic Acid as Prevention for Early Postoperative Bleeding after Roux-en-Y Gastric Bypass.

João Victor Vecchi Ferri, Marcela Scardua Cocicov, Vitor Mamoru Haida, José Alfredo Sadowski, Wagner Herbert Sobottka, Gustavo Rodrigues Alves Castro, João Caetano Dallegrave Marchesini, Alexandre Coutinho Teixeira de Freitas

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Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

João Victor Vecchi FerriClinical Hospital Complex of the Federal University of Paraná, Curitiba, Paraná, Brazil. drjoaoferri@gmail.com.
Marcela Scardua CocicovSão Marcelino Champagnat Hospital, Curitiba, Paraná, Brazil.
Vitor Mamoru HaidaSão Marcelino Champagnat Hospital, Curitiba, Paraná, Brazil.
José Alfredo SadowskiSão Marcelino Champagnat Hospital, Curitiba, Paraná, Brazil.
Wagner Herbert SobottkaSão Marcelino Champagnat Hospital, Curitiba, Paraná, Brazil.
Gustavo Rodrigues Alves CastroSugisawa Hospital, Curitiba, Paraná, Brazil.
João Caetano Dallegrave MarchesiniSão Marcelino Champagnat Hospital, Curitiba, Paraná, Brazil.
Alexandre Coutinho Teixeira de FreitasClinical Hospital Complex of the Federal University of Paraná, Curitiba, Paraná, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative bleeding (POB) after Roux-en-Y gastric bypass (RYGB) occurs in up to 4.1% of cases and is associated with increased 30-day mortality, transfusions, and reinterventions.

methodsThis study evaluated whether tranexamic acid (TXA) administered during anesthetic induction reduces clinical POB within 48 h after primary laparoscopic RYGB. Secondary outcomes included risk factors for POB, thromboembolic events (TEE), and mortality. In this mixed cohort study, consecutive patients undergoing RYGB between 2020 and 2025 were divided according to systematic TXA use.

resultsAmong 678 patients, 347 (51.2%) received TXA. This group’s mean age was 37 years and their mean BMI 40.4 kg/m². POB occurred in 21 patients (3.1%). TXA significantly reduced POB risk (OR 4.25; p = 0.007). Being of male sex increased POB risk (OR 2.59; p = 0.031). No differences in TEE or mortality were observed.

conclusionsTXA reduced POB risk by 70–78%. It was also noted that male sex was an independent risk factor.

Indexed as

Antifibrinolytic AgentsGastric BypassObesity, MorbidPostoperative HemorrhageTranexamic AcidAdultFemaleHumansLaparoscopyMaleMiddle AgedRetrospective StudiesRisk FactorsAntifibrinolytic AgentsTranexamic AcidBariatric surgeryObesityPostoperative hemorrhageRoux-en-Y gastric bypassThromboembolismTranexamic acid

Identifiers

PMID41989749
PMCPMC13222330

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.