Evidence map›Paper›PMID 41990259›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Sex-Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu-erh Tea.

Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao and 13 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yang LiCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Junliang KuangCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dan ZhengCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jieyi WangCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kun GeCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chun QuCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaojiao ZhengCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhenxing RenCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fengjie HuangHuman Metabolomics Institute, Inc., Shenzhen, China.
Mingliang ZhaoCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yimin SunCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huiheng ZhangCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Keke DingCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xixi XiaCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yajun TangCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lu LiuDepartment of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China.
Jian ZhouDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fei GaoDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaohui MaTasly Research Institute, Tianjin, China.
Yongquan XuTasly Research Institute, Tianjin, China.
Guoxiang XieHuman Metabolomics Institute, Inc., Shenzhen, China.
Aihua ZhaoCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei JiaCenter For Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-3739-8994

Funding

National Key R&D Program of China 2021YFA1301300National Key R&D Program of China 2022YFA0806400National Natural Science Foundation of China 82122012National Natural Science Foundation of China 82170833National Natural Science Foundation of China 82270917Shanghai Research Center for Endocrine and Metabolic Diseases 2022ZZ01002
6 · The paper itself

Abstract

Theabrownin (TB) from Pu-erh tea has demonstrated efficacy in alleviating hyperglycemia, yet its mechanism remains incompletely understood. In our study, we found that Pu-erh tea or TB intervention effectively lowered postprandial blood glucose levels in females with normal and impaired glucose tolerance (IGT), as well as in hyperglycemic mouse models. Specifically, oral administration of Pu-erh tea or TB led to the inhibition of small intestinal α-glucosidase activity in a female-specific manner. TB's inhibition of α-glucosidase in vivo was significantly enhanced by mucin 2 (MUC2), a protein enriched in female intestinal mucin and upregulated by estradiol. Through noncovalent interactions, TB binds to MUC2 to form a complex, significantly boosting its inhibitory effect on α-glucosidase in females. These findings reveal the sex-specific molecular mechanism underlying the blood glucose-lowering effects of TB from Pu-erh tea, offering a promising intervention for maintaining glycemic balance in individuals with IGT or type 2 diabetes. Additionally, our study highlights the importance of considering sex differences in the judicious use of supplements or pharmacotherapy.

Indexed as

Blood GlucoseCatechinHomeostasisHyperglycemiaTeaAnimalsFemaleMaleMiceSex FactorsBlood GlucoseCatechinTeahyperglycemiaMUC2sex differencesTheabrowninα‐glucosidase

Identifiers

PMID41990259
PMCPMC13335617

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.