ArticleNature communications2026
Conserved and divergent gene regulatory networks for crop drought resistance.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Multitrait Evaluation of Drought Tolerance at the Seedling Stage in Advanced Backcross Germplasm Derived from Sugarcane ×Plants (Basel, Switzerland) · 2026Article
- Comparative Transcriptomic Analysis of Water-Deficit Responses inInternational journal of molecular sciences · 2026Article
- Integrated multi-omics profiling reveals dynamic regulation of light-induced chloroplast biogenesis in Brassica napus seedlings.Nucleic acids research · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
Understanding crop drought resistance mechanisms is critical for enhancing resilience to intensifying climate change. However, the conserved and divergent drought resistance mechanisms under the genetic basis across species remain unclear. Here, using an innovative graph-based deep learning framework, we construct drought-responsive large-scale gene regulatory networks (GRNs) across transcriptional, proteomic, and metabolic layers in major Poaceae crops integrating over 5000 bulk RNA-seq datasets to map 3.3 million interactions among 130,000 genes. Other crops in Fabaceae and Solanaceae are also included for further validation. Large-scale data and advanced algorithms provide rigorous, genome-wide evidence and insights into drought GRNs. We find robustly conserved interaction patterns of TCP-PP2C and ERF-2OGD linked to abscisic acid and redox regulation. Divergent mechanisms are identified, including SPL-PELP in rice/wheat lineage and ERF-Psb28 in maize/sorghum lineage from large-scale comparative network analysis. We propose the hypothesis that drought resistance in crops is phylogenetically constrained by the topological structure of GRNs, rather than just a few key genes. Drought resistance of representative C
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