Evidence map›Paper›PMID 41991817›Full record

ArticleDiscover oncology2026

Early postoperative neutrophil to lymphocyte and platelet to lymphocyte ratios predict postoperative complications after curative surgery for locally advanced rectal cancer.

Mahmoud Al-Masri, Yasmin Safi, Mohammad Almasri, Ramiz Kardan, Daliana Mustafa, Bilal Kahalah, Ola Ramadan, Rama Almasri

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PubMed Full text at PMC Publisher
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Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mahmoud Al-MasriDepartment of Surgery, King Hussein Cancer Center, Queen Rania Al Abdullah Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan. malmasri@khcc.jo.
Yasmin SafiDepartment of Surgery, King Hussein Cancer Center, Queen Rania Al Abdullah Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Mohammad AlmasriDepartment of Surgery, King Hussein Cancer Center, Queen Rania Al Abdullah Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Ramiz KardanDepartment of Surgery, King Hussein Cancer Center, Queen Rania Al Abdullah Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Daliana MustafaOffice of Research and Affairs, King Hussein Cancer Center, Amman, Jordan.
Bilal KahalahDepartment of Surgery, King Hussein Cancer Center, Queen Rania Al Abdullah Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Ola RamadanDepartment of Surgery, King Hussein Cancer Center, Queen Rania Al Abdullah Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Rama AlmasriDepartment of Surgery, King Hussein Cancer Center, Queen Rania Al Abdullah Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative inflammation is critical determinant of recovery and outcomes in patients undergoing locally advanced rectal cancer (LARC) surgery. Early biomarkers such as neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios may predict short-term complications. This study aimed to assess association between postoperative NLR and PLR and early postoperative complications in LARC patients.

methodsIn this retrospective cohort study, 261 LARC patients undergoing curative-intent resection (2014–2024) at King Hussein Cancer Center were included. Postoperative Day 1 NLR and PLR were extracted from laboratory records, and 30-day complications from electronic medical records. Mann–Whitney U tests, logistic regression, and ROC curve analysis were used to assess the predictive value of these markers.

resultsAmong 261 patients, 39.1% (n = 102) experienced at least one postoperative complication. The most frequent complications were stoma-related issues (24.1%), followed by surgical site infection (7.3%), anastomotic leak (3.4%), bleeding (3.1%), and venous thromboembolism (1.9%). Readmission and reoperation rates were 3.8% and 2.7%, respectively. Patients with complications had significantly higher inflammatory marker levels, including median NLR (4.92 vs. 2.88) and PLR (317.32 vs. 202.88), both p < 0.001. ROC analysis identified cutoff points of 4.96 for NLR and 185.99 for PLR. In multivariable logistic regression, elevated NLR independently predicted postoperative complications (OR = 3.0; 95% CI: 1.56–5.76), adjusting for clinical and treatment-related factors. Subgroup analysis showed lower postoperative inflammatory markers among patients receiving total neoadjuvant therapy (TNT) compared with chemoradiotherapy (CCRT), and among those undergoing minimally invasive surgery (MIS) compared with open surgery (all p < 0.001).

conclusionNLR and PLR are early predictors of postoperative complications in LARC surgery, while TNT and MIS reduce inflammatory response and complications. Monitoring these markers may improve risk stratification and patient management.

Indexed as

Chemoradiotherapy (CRT)Inflammatory biomarkersLocally advanced rectal cancer (LARC)Neutrophil-to-lymphocyte ratio (NLR)Platelet-to-lymphocyte ratio (PLR)Postoperative outcomesPrognostic indicatorsTotal neoadjuvant therapy (TNT)

Identifiers

PMID41991817
PMCPMC13201703

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.